Mexiletine Banishes Muscle Cramps in Phase 2 Trial of ALS
Scientists wonder if the sodium channel blocker might also slow disease progression.
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Acetylated Tau Mucks Up Memories
The modified protein prevents the synaptic protein KIBRA from managing plasticity.
Can’t Degrade That Pesky Misfolded Protein? Push It Off the MAPS
Not exosome, not proteasome, not autophagy: Could a new pathway dubbed MAPS facilitate the spread of amyloidogenic proteins?
In First Phase 3 Trial, the Tau Drug LMTM Did Not Work. Period.
Claims of a positive effect in a small subgroup of patients are statistically meaningless, experts say.
Paper Alert: Aducanumab Phase 1b Study Published
The monoclonal antibody appears to remove plaques, although the small trial could not draw conclusions about cognition.
Immune Receptor May Smuggle α-Synuclein into Neurons, Hasten Proteopathy
The LAG3 transmembrane protein latches onto fibrillar forms of the synaptic protein and ushers them into neurons. Researchers propose targeting LAG3 to slow toxic spread of misfolded forms of synuclein.
Once Again, Statins Found to Reduce Alzheimer’s Risk
Despite conflicting results in the past, a large new study analyzing multiple statins in different ethnic groups suggests a protective effect from this class of medication.
Transport Breakdown Maroons BACE1 in Synapses, Boosts Aβ
Restoring normal transport of BACE1-carrying endosomes prevents synapse loss and cognitive decline in mice.
From Garbage Disposal to Neuromodulation? Membrane Proteasomes Churn Out Stimulating Peptides
In a bizarre twist of cell biology, researchers find proteasomes in the neuronal plasma membrane. They pump signaling peptides into the extracellular space.
Finally, a Dye to Visualize Pericyte Function
A new fluorescent compound labels only non-contractile cells in the capillary bed, supporting the idea that these mysterious little cells do not directly regulate brain blood flow.
Do Perivascular Macrophages Mediate Aβ Pathology?
Researchers implicate these innate immune cells in the disruption of neurovascular coupling by Aβ in mice.
Trigger Warning: α-Synuclein Sets Off T Cells in Parkinson’s
White blood cells from certain Parkinson’s patients react to α-synuclein peptides. Is this autoimmune reaction why the major histocompatibility complex is genetically linked to the disease?
Ring Around the Vessel: Enlarged Spaces Signal Vascular Disease
Gaps surrounding blood vessels in the brain may predict cognitive decline and vascular dementia.
As Youth Fades, So Does the Fire of Glycolysis in the Brain
The aging brain winds down rapid glucose metabolism in regions that will go on to accumulate amyloid, perhaps raising the risk of neurodegeneration.
Can Biomarker Data Predict Individual Risk for Alzheimer’s?
Researchers debut a statistical model that uses MRI, CSF, and demographic data to compute a cognitively impaired person’s risk for progressing to dementia.
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