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Collaborative research directed by Floyd E. Bloom of Neurome Inc. and the Scripps Research Institute shows that dramatic changes occur in the brains of mice expressing mutant human forms of AβPP long before any Aβ has been deposited...
Researchers working on NSAIDs as potential treatments for AD are discussing whether a large ongoing prevention trial of two such anti-inflammatories is testing the right drugs.
The drug memantine can benefit patients with moderate to severe Alzheimer's disease, according to a study reported in the April 3 New England Journal of Medicine...
For several years now, the Alzheimer's research and treatment communities have been awaiting the fruition of promising research into quantitative imaging agents that could signal the presence of amyloid...
In Alzheimer and some other neurodegenerative diseases, the microtubule-associated protein tau weaves a web of neurofibrillary tangles (NFTs) that might...
Depending on how you slice the epidemiological pie, the use of cholesterol-lowering statins could appear to...
The tumor suppressor and apoptotic transcription factor p53 has been linked to Alzheimer disease in numerous ways, but perhaps the most direct link is...
The vascular hypothesis of Alzheimer disease suggests that pathology starts with hypoperfusion, or decreased blood flow to the brain...
A comprehensive proposal of new diagnostic criteria marked a highlight at the International Conference on Alzheimer’s Disease...
For the first time, a paper details a molecular mechanism that links tau to Aβ toxicity at the synapse...
Scientists have uncovered a fresh clue in the mystery that is amyotrophic lateral sclerosis...
Experimental evidence and plain common sense tell us that neurons lose activity in Alzheimer disease...
A large, collaborative group led by Julie Andersen at the Buck Institute for Research in Aging, Novato, California, demonstrates that lowering the bioavailability of iron—both systemically and in dopaminergic neurons—protects mice against chemically induced Parkinson's...
The tight barrier between brain and blood vessels guards the brain from harm, but also frustrates scientists trying to deliver therapeutic molecules to the CNS...
Like good cholesterol and bad cholesterol, the Alzheimer's community has realized that there may also be good Aβ and bad Aβ...
