Peter Davies, Beloved Giant of Alzheimer’s Disease Research, Dies at 72
In a career spanning four decades, Davies spearheaded the cholinergic hypothesis, unlocked secrets of tau, and readily shared antibodies in the field.
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Dale Schenk, 59, Pioneer of Alzheimer’s Immunotherapy
Schenk loses two-year battle with pancreatic cancer.
Field Loses Beloved Wizard of Glia, Ben Barres, 63
Pancreatic cancer felled the man who led groundbreaking research on astrocytes, oligodendrocytes, and microglia.
Mark Smith, 45, Is Struck and Killed by Hit-and-Run Driver
As shocked researchers notify each other privately, the Alzforum editors are saddened to inform the community at large that Mark Smith died last Sunday...
Biogen/Eisai Halt Phase 3 Aducanumab Trials
Futility analysis predicts failure to reach primary endpoint.
Coronavirus Takes Its Toll on Alzheimer’s Clinical Studies
Most observational cohorts are on pause, and many clinical trials have stopped dosing. The long-term effects on the integrity of AD studies are unclear.
‘Reports of My Death Are Greatly Exaggerated.’ Signed, Aducanumab
After shutting down a Phase 3 program last March, Biogen now says the futility analysis it did was incorrect, and that a new analysis of a larger dataset in fact supports filing for FDA marketing approval next year.
Aducanumab Still Needs to Prove Itself, Researchers Say
While the FDA weighs aducanumab’s marketing license application, Alzheimer’s researchers agree that the agency’s own statistician correctly assessed the data as weak. Most prefer that one more trial be done.
Familial AD Mutations, β-CTF, Spell Trouble for Endosomes
Using a collection of isogenic iPSC-derived neurons harboring different familial AD mutations, researchers found that, across the board, the mutations meddled with endosomes via elevated β-CTF.
Bapineuzumab Phase 3: Target Engagement, But No Benefit
Bapineuzumab prevents accumulation of Aβ in the brain and lowers phospho-tau (p-tau) in cerebrospinal fluid (CSF), according to analysis...
Field Loses Another Pioneer with Passing of Allen Roses, 73
Discoverer of ApoE4 risk allele died of a heart attack.
New Definition of Alzheimer’s Hinges on Biology, Not Symptoms
For the first time, NIA-AA proposal bases diagnosis in living people solely on biomarkers for plaques and tangles.
Anne Cataldo, 57, Autophagy Researcher Known for Generous Collegiality
It is with deep sadness that we inform the Alzheimer research community of the passing of Anne Cataldo...
BAN2401 Removes Brain Amyloid, Possibly Slows Cognitive Decline
Researchers consider the data encouraging, though questions linger about the cognition results. Did regulators mess up the randomization of this trial?
Colleagues Mourn Loss of Rahul Desikan, Age 41, to ALS
Desikan pioneered advances in neuroimaging and neurogenetics, and was known for his passion and collaborative spirit.
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