Senate Ups Funding for Alzheimer’s Research by $350 million for 2020
Bringing the total NIH funding for Alzheimer’s research up to $2.8 billion, the Senate continued its steady upward climb in spending for the disease.
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Clinical Trials on Alzheimer's Disease 2019
Exposure, Exposure, Exposure? At CTAD, Aducanumab Scientists Make a Case Fluid AD Biomarkers Link P-Tau to Synapses, Inflammation Blood Tests of Phospho-Tau, Aβ42, Track With Brain Amyloid Amyloid Clearance: Check. Cognitive Benefit: Um … Maybe. Picking ...
CTAD Lessons for 2020: More Phase 2 Trials, More Diversity
Besides further broadening the Alzheimer’s therapeutic pipeline, researchers urge a return to Phase 2, using artificial intelligence tools to streamline aspects of trials.
Fluid AD Biomarkers Link P-Tau to Synapses, Inflammation
An expanded set of CSF biomarkers exposed tight connections between p-tau, synaptic dysfunction, and neuroinflammation in people with brain amyloid.
Could New Glutamate Receptor Activators Treat Alzheimer’s?
Positive allosteric modulators improve learning and memory in mouse models of AD and epilepsy.
Tangle Density Foretells How Fast a Person’s Brain Will Shrink
In early Alzheimer’s disease, the pattern of tau deposition also strongly predicts areas destined for subsequent degeneration.
Paper Alert: Lipid Droplet-Filled Microglia Harm the Brain
These oily microglia resemble the foamy macrophages seen in atherosclerotic plaques. They correlate with aging, inflammation, and neurodegenerative disease.
In AD, Chaperones Congregate To Form a Therapeutic Target
Aberrant protein-protein interactions centered on HSP90 may contribute to Alzheimer’s disease. Can an inhibitor set things right?
Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers
Frequent heading weakened verbal memory in amateur soccer players, and more so in ApoE4 carriers.
Does Young-Onset Parkinson’s Arise in Lysosomes?
Poor lysosomal function in dopaminergic neurons derived from people with YOPD points to disease origin and potential therapies.
Tau PET Scans Turn Positive When Amyloid Does; Symptoms Follow
Data from different next-generation tracers look similar. It shows spreading plaques kick off tangles by Braak region; memory starts slipping later.
Multimodal Imaging of Neurodegenerative Diseases Links Pathology and Cellular Dysfunction
Synapse loss and mitochondrial stress, as seen by separate PET tracers, go hand-in-hand in Alzheimer’s, Parkinson’s, and frontotemporal dementia.
Paper Alert: Phase 3 Trial Data Published on Sleep Aid Suvorexant
FDA approves adding safety and efficacy data from an Alzheimer’s trial to the drug’s label.
New Myelin Makes Memories, but Supply Wanes with Age
The creation of long-term memories requires a continual supply of myelin provided by newly formed oligodendrocytes. Alas, the generation of fresh oligodendrocytes diminishes with age, along with memory.
Retinal Gene Therapy Trial Posts Positive Result
Vision improved in some retinitis pigmentosa patients in a Phase 1 trial.
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