CPTX—A Synaptic “Glue” Restores Memory in Alzheimer’s Model
The designer chimera stabilizes synapses in various mouse models of neurodegenerative disease.
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Deep Sleep Makes Waves for CSF
Slow-wave sleep brings on coordinated oscillations in blood flow, which in turn are coupled to waves of cerebrospinal fluid. The data point to a mechanism linking deep sleep to the flow of CSF.
Small Molecules Liven Up Lethargic Lysosomes in Parkinson’s Neurons
Two papers used different approaches to energize laggard lysosomal function in neurons derived from people with Parkinson’s. Both restored lysosomal trafficking and reduced α-synuclein accumulation.
The Human Brain Hosts a Menagerie of Microglia
Brain biopsy tissue reveals that their transcriptomes shift by location, age, and disease.
Time to Try Again: Gene-Based Therapy for Neurodegeneration
Encouraged by success in treating infant spinomuscular atrophy, researchers are redoubling their efforts to target genetic causes of age-related neurodegeneration.
Gene Therapies Enter Trials for Many Brain Pathologies—What about AD?
As gene therapy is making a comeback, scientists are exploring if it might prevent or reverse Alzheimer’s. Some of those treatments are permanent, heightening safety concerns.
Vascular Dysfunction Taxes Cognition, but Not Via Amyloid, AD
Three studies found no link between vascular disease and cerebral amyloidosis.
In Aging, Epigenetic Wet Blanket Douses Mitochondria
Two epigenetic proteins accelerated age-related behavioral decline in worms and in mice, at least partly by dampening mitochondrial function. Orthologs in the human brain ramped up with aging and with AD progression.
Without TMEM106B, Lysosomal Traffic Jams Wreak Havoc in Neurons
In motor neurons of TMEM106b knockout mice, swollen vacuoles piled up in axons near the soma, rendering the mice wobbly and slow to react. The finding contradicts prior reports.
Different CSF Phospho-Taus Match Distinct Changes in Brain Pathology
Different forms of p-tau in cerebrospinal fluid reflect worsening plaque load, metabolism, and atrophy in the brain. They could help stage Alzheimer’s disease.
Does Alzheimer’s Start in the Heart of the Cholinergic System?
In people with Alzheimer’s biomarkers, the basal forebrain shrinks early, foreshadowing microglial neurotoxicity, atrophy in the medial temporal lobe, and cognitive decline.
Aβ in Lewy Body Disease: Two Diseases at Once, or Another Beast Entirely?
For people with Parkinson’s, carrying Alzheimer’s genetic risk variants upped their odds of harboring Aβ and tau pathology and getting dementia. In people with DLB, Aβ plaques worsened tau and Lewy pathology, and cognition.
Flortaucipir Autopsy Study Published
Avid’s postmortem validation data indicate Alzheimer’s can be diagnosed by visual examination of flortaucipir PET scans.
Paul Taylor Wins 2020 Potamkin Prize
Award recognizes discoveries of genetic variants that perturb liquid-liquid phase separation and increase risk for ALS-FTD and other neurodegenerative diseases.
Umbilical Cord With Presenilin Mutation Births New Cell Model of Familial AD
Umbilical cord stem cells from presenilin 1 E280A carriers, once differentiated into cholinergic-like neurons, pumped out Aβ42 and accumulated phosphorylated tau and apoptotic markers.
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