Paper Alert: Those PIGs! Spatial Transcriptomics Add Human Data
In the Alzheimer’s brain, too, plaques trigger a coordinated inflammatory response from microglia and astrocytes. A preprint paper had shown the same for mice.
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Rogue APP Claim Embroiled in Contamination Concerns
A 2018 report that had spotted extra copies of APP lurking in neuronal genomes has come under scrutiny, with claims that the result is due to contamination. Does a response from the original authors bolster their claim?
CPTX—A Synaptic “Glue” Restores Memory in Alzheimer’s Model
The designer chimera stabilizes synapses in various mouse models of neurodegenerative disease.
Mysterious RNA Circles Crop up in Alzheimer’s Brain
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
Simulating Tangle Spread Along Axons, Scientists Predict Tau PET Patterns
The modeling approach reinforces the idea that tau pathology propagates through the brain’s physical architecture, including neuronal networks.
LRRK2 Mutation Fires Up Immune Response, Harms Brain
The G2019S variant that boosts Parkinson’s risk helps mice survive infection, but raises α-synuclein in the brain and increases neuronal death.
Does Your Personality in High School Foretell Your Dementia Risk?
Based on high school personality tests taken nearly 60 years ago, researchers associated certain traits with future risk of dementia.
Deep Sleep Makes Waves for CSF
Slow-wave sleep brings on coordinated oscillations in blood flow, which in turn are coupled to waves of cerebrospinal fluid. The data point to a mechanism linking deep sleep to the flow of CSF.
Small Molecules Liven Up Lethargic Lysosomes in Parkinson’s Neurons
Two papers used different approaches to energize laggard lysosomal function in neurons derived from people with Parkinson’s. Both restored lysosomal trafficking and reduced α-synuclein accumulation.
Not Just Blood Pressure—Dietary Salt Linked to Tau Phosphorylation
Cognitive deficits in mice on a high-salt diet are due to tau phosphorylation, not reduced blood flow, according to a new study.
The Human Brain Hosts a Menagerie of Microglia
Brain biopsy tissue reveals that their transcriptomes shift by location, age, and disease.
Time to Try Again: Gene-Based Therapy for Neurodegeneration
Encouraged by success in treating infant spinomuscular atrophy, researchers are redoubling their efforts to target genetic causes of age-related neurodegeneration.
Gene Therapies Enter Trials for Many Brain Pathologies—What about AD?
As gene therapy is making a comeback, scientists are exploring if it might prevent or reverse Alzheimer’s. Some of those treatments are permanent, heightening safety concerns.
Vascular Dysfunction Taxes Cognition, but Not Via Amyloid, AD
Three studies found no link between vascular disease and cerebral amyloidosis.
2019—A Year of Hope for Alzheimer's Research
Happy New Year, readers! Yes, 2019 has passed, but so much happened last year that capturing the essence took longer than usual. Our mega year-end story is now posted for your reading pleasure.
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