Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third
Massive meta-analysis finds the longevity gene’s VS haplotype staves off mild cognitive impairment and AD. It reduces amyloid burden.
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Mouse Brain Mapped in 3D, at High Resolution
This update of the Allen Brain Institute atlas reveals detailed anatomical structures and provides a common framework for comparing brain datasets.
Massive Proteomics Studies Peg Glial Metabolism, Myelination, to AD
Separately, cerebrovascular disease drove an uptick in neurofilament light in the brain, indicating neurodegeneration.
In Colombian Alzheimer’s Kindred, Blood NfL Climbs 22 Years Before Symptoms
The plasma biomarker neurofilament light was able to distinguish individual mutation carriers from noncarriers three years prior to onset.
Simulating Tangle Spread Along Axons, Scientists Predict Tau PET Patterns
The modeling approach reinforces the idea that tau pathology propagates through the brain’s physical architecture, including neuronal networks.
New Astrocyte Marker Allows Purification from Mixed Cultures
Researchers identify a way to isolate human astrocytes generated from induced pluripotent stem cells. And astrocytes stand out in FTD-prone brain areas.
Alzheimer’s Research Restarts, Cautiously
As the SARS-Cov-2 infection peak passes in some areas, scientists are resuming lab work and clinical studies, albeit with new safety protocols in place. Regions differ greatly in how fast they can reopen.
TMEM106B Variants Regulate Gene Modules, TDP-43 Pathology
A GWAS of co-expression modules identifies a haplotype that disrupts lysosomes and myelination. ApoE4 and Aβ regulate the same module.
CryoEM of CBD Tau Suggests Another Unique Protofibril
Post-translational modifications differ from those in AD tau fibrils, and may dictate tau strains.
Can BACE2 Protect Against Amyloidosis?
The protease suppresses Aβ in Down’s syndrome organoids.
Neuronal SRPX2 Spoils Microglial Appetite for Synapses
This neuronal protein regulates the complement cascade in the developing brain. Could it do the same in aging or neurodegenerative disease?
Klotho VS Variant Preserves Memory by Preventing Tangles
Carriers accumulate fewer tangles than noncarriers for a given amount of amyloid, explaining how the gene variant may lower a person’s Alzheimer’s risk.
Tunneling Nanotubes—How Pericytes Control Blood Flow
In the mouse retina, these tender threads connect pericytes on nearby capillaries. They enable cells to coordinate constriction and dilation of blood vessels in response to neuronal activity.
Can Loss of a Single Protein Domain Cause ‘Alzheimer’s’ in Mice?
Without the WD domain of Atg16L1, required for a newly discovered type of endocytosis, old mice develop hallmark pathologies of AD.
With Tau in Synapses, NO Neurovascular Coupling
Dendritic tau suppresses production of nitric oxide, which prevents blood vessels from dilating in response to neural activity.
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