Toxic Stew of Aβ Dimers Hides Out in Human Plaques
Brains of Alzheimer’s patients contain Aβ dimers consisting of monomers Aβ37 to Aβ42 and held together by covalent bonds.
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It’s Official: Tau PET Sees Tangles, and Staging Tangles Predicts Decline
Scientists at CTAD were excited about postmortem validation of tau scans and new, more sensitive tracers. Others are exploring practical applications for live imaging of tau pathology.
Amyloid PET Aids Diagnosis. But Could CSF Do Just as Well?
Large IDEAS data set establishes that PET scans are valuable in clinical practice. Other studies suggest CSF biomarker ratios perform nearly as well.
Not Just Motoneurons: Sensory Neurons Suffer Effects of ALS
Cultured sensory neurons from ALS mouse models have truncated, less-complex neurites that grow slowly compared to controls.
Is NfL the New 'N' in A/T/N Classification of Alzheimer’s?
People with a lot of neurofilament light protein in their spinal fluid are more likely to develop mild cognitive impairment in the next four years.
Trial-Ready Cohorts Take Shape in Europe and U.S.
At CTAD, researchers discussed baseline data from the first 500 participants in the EPAD cohort and, finally, the start of recruitment for TRC-PAD.
Progranulin: A Mark of Worsening Alzheimer’s?
In sporadic and familial forms of AD, progranulin climbs in the cerebrospinal fluid as disease progresses, perhaps reflecting microglial activation.
Could an Aspirin a Day Keep Multiple Sclerosis at Bay?
In mice, a daily low dose restored regulatory T cells and held off symptoms of a demyelinating disease. Could an old, over-the-counter drug help with ALS, in which similar cells decline?
Imaging Data Resurrects Abandoned Parkinson’s Gene Therapy
FDG PET revealed the formation of a new functional brain network. It explains clinical improvements noted previously.
5th RNA Metabolism in Neurological Disease Conference
It’s ‘And,’ Not ‘Either-Or’: C9ORF72 Mechanisms of Action are Linked Beyond the Nucleus: TDP-43 Sticks Together, For Better or Worse Going the Distance: FUS Travels to Terminals, Drops Off RNA When RNA transcripts aren’t processed properly or don’t make ...
Going the Distance: FUS Travels to Terminals, Drops Off RNA
Scientists say chaperones keep FUS from joining up with aggregating proteins as FUS makes its way down axons to deliver RNAs for local translation. ALS/FTD mutations bungle the process.
Natural History Studies Provide Foundation for FTD Research
At ICFTD in Sydney, researchers update the community on ARTFL/LEFFTDS.
Tracking Onset and Progression of Frontotemporal Dementia
New scales debuted at ICFTD could help clinical trials.
Neurofilament Light: A Universal Mark of Neurodegeneration
In patients across a range of neurodegenerative diseases, NfL ramps up in the cerebrospinal fluid. Levels are higher in those with worse disease.
First Round of Awards from Chan Zuckerberg Initiative Announced
The awards total $52 million, divided among 17 early career investigators and nine collaborative science teams.
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