A DNA Vaccine for AD? New Strategy Looks Good in Monkeys
A DNA-based Aβ vaccine appears safe and produces a strong immune response in monkeys, suggesting it could work in people.
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A DNA-based Aβ vaccine appears safe and produces a strong immune response in monkeys, suggesting it could work in people.
Neurons clear misfolded proteins at different speeds. Is this why some brain regions are more vulnerable to neurodegeneration than others?
Knocking down tau expression in adult mice diminishes induced seizures.
Mass spectrometry data show how γ-secretase modulators skew APP processing toward Aβ40 rather than Aβ42, without upsetting cleavage of other substrates.
Tau ligands for PET scans were among the hot topics at the Alzheimer’s Association International Conference in Boston.
Studies reported at AAIC demonstrate that biomarkers help predict who will develop cognitive impairment and dementia.
Motor and cortical neurons are particularly vulnerable to FUSopathy. A new paper suggests they fail because they depend strongly on FUS to regulate transcription.
Researchers identified a genetic variant in the microglial gene CD33 that protects against Alzheimer’s.
Alzheimer’s and prion disease may be linked through an α-secretase.
The route to early dementia starts in adolescence, with low cognitive function and alcohol intoxication as major predictors.
Expansions in ataxin-2 can lead to either ALS or spinocerebellar ataxia—even in the same family, according to a new pedigree from New York.
Two studies examine factors that heighten the risk for dementia in type 2 diabetes patients. Both highlight depression as a dangerous comorbidity.
A stem cell-derived structure mimics crucial features of human brain development and could aid studies in schizophrenia, autism, maybe neurodegeneration.
Functional genomics and mouse analyses blame waning levels of histone-binding protein for memory loss in aging.
Researchers say that analyzing long stretches of homozygosity in people of Caribbean Hispanic descent represents an approach to finding rare, recessive Alzheimer’s mutations.