New Drug Discovery Institutes to Tackle AD in the U.K.
Alzheimer's Research UK has funded institutes at three universities to turn academic ideas into drug candidates.
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Alzheimer's Research UK has funded institutes at three universities to turn academic ideas into drug candidates.
Routine cognitive screening could help doctors spot people at risk of dementia. Two new tests could make screening more accessible.
Skin side effect under investigation.
In mice, the presence of mutant human tau disrupts synaptic signaling and slows down neuronal firing.
Simple survey touted as a potential functional outcome in prevention trials.
The brain’s resident immune cells secrete galectin-3, which activates other nearby microglia to promote neuroinflammation.
In mice lacking BACE1, fewer potassium ions escape hippocampal neurons, causing brain cells to fire more rapidly.
When ultrasound opens the blood-brain barrier in mice, microglia engulf plaques.
Risk alleles of SORL1 dampen its expression in response to growth factors, leading to higher Aβ production.
The ALS- and FTD-linked expansion, once it reaches more than 90 repeats, always manifests methyl groups.
Similar regulators could be the next frontier in neurodegeneration studies, scientists say.
Researchers at a Keystone meeting reported that a combination of protective and destructive signals target microglia to prune synapses in the brain. These signals may be altered during disease.
A chloride ion imbalance renders γ-aminobutyric acid (GABA) receptors excitatory.
The British government, pharmaceutical companies, and a research charity establish a venture capital fund.
Cognitively normal people with levels of CSF Aβ42 near the cutoff point associated with amyloid pathology are likely to cross that threshold within three years.