Is Alcohol Abuse a Bigger Dementia Risk Than We Thought?
Health records from 31 million French people suggest that drinking to excess is a major risk factor for early onset dementia.
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Health records from 31 million French people suggest that drinking to excess is a major risk factor for early onset dementia.
Scientists found FUS interacts with Argonaute, miRNAs, and targets mRNAs to quell gene expression.
Ionis Pharmaceuticals reported positive top-line data from the Phase 1/2a trial of its ASO.
World’s biggest brain research award goes to European leaders on Aβ tau and TREM2.
A winter storm cut the meeting short, but not before attendees learned that viral load correlates with clinical and pathological traits of AD.
Voyager Therapeutics announced positive interim results from a small, ongoing Phase 1b trial in people with advanced PD.
A family of petite, RNA-directed nucleases offers a platform for finessing the transcriptome.
Kinesin mutations may disrupt organelle transport, putting motor neurons at risk.
No benefit detected in double-blind trial with sham surgical controls.
After Plasma Aβ, Now Plasma P-Tau181 Shows Promise To Block Tau’s Proteopathic Spread, Antibody Must Attack its Mid-Region DIAN and ADNI Data Say Familial and Sporadic AD Converge News From the PET Front: Early Amyloid Networks and Tau Mystery Alzheimer’s
The epitope that a therapeutic tau antibody targets determines whether it prevents seeding in cellular assays, raising questions about first-generation antibody trials.
A comparison of these large data sets shows that while the two forms of Alzheimer’s disease have separate triggers, they follow the same course and are much more similar than different.
At AAT-AD/PD, scientists showed that correlated amyloid patches are an even earlier marker than brain-wide positivity, while others puzzled over why tau signals are lower in older people.
An antagonist to this receptor was trounced in Phase 3 trial.
A widely popularized finding of shrinking dementia rates is entirely due to less vascular dementia, and is in fact concealing a rise in AD and PD, according to a provocative talk at AAT-AD/PD.