Truly New to Déjà Vu: For Five Hopefuls, Lights Go Out After Phase 2
At CTAD, a handful of candidate therapies were reported to have flamed out in Phase 2. They were unable to show efficacy. A new antipsychotic is entering the ring.
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At CTAD, a handful of candidate therapies were reported to have flamed out in Phase 2. They were unable to show efficacy. A new antipsychotic is entering the ring.
At CTAD, investigational Phase 1 drugs include a repackaged and a new anti-amyloid, a tau vaccine, and a repurposed cancer drug.
The leaders of two large European trials report that promoting cardiac health, exercise, and mental activity helped maintained cognition in older adults.
Forget transgenics for a moment. Large collections of inbred and outbred mice could be an untapped treasure trove for Alzheimer’s researchers.
Researchers at this year’s SfN meeting detailed different strategies and outcomes of passive and active vaccines.
Mouse lines made by two different labs replicate the molecular pathology, but not the neurodegeneration, of ALS and FTD based on C9ORF72 expansions.
The BRCA1 protein protects neurons from DNA damage, but levels tumble in Alzheimer’s disease.
NIH announced a five-year study of Alzheimer’s biomarkers in middle-aged people with Down’s syndrome.
Trials of gene therapy for spinomuscular atrophy and stem cell treatments for ALS look promising.
Gene and Stem Cell Therapies Make Strong Showing at ALS/MND Meeting Help for Speech, Swallowing, and Salivation Problems in ALS Does Free Radical Scavenger Edaravone Slow ALS? SOD1, Tau Swept Up in Prion-like Biology at ALS Meeting At the International Sy
Dementia with Lewy Bodies: Is the Research Ready For Clinical Trials Through the Heart? Cardiology Tracer to Nail DLB Diagnosis Dementia with Lewy Bodies: Sharper Image for a Formerly Blurry Disease Brain Imaging: What Does it See in DLB? Lewy Pathology i
At the International Dementia with Lewy Bodies conference in Fort Lauderdale, Florida, fuzzy images of dying sympathetic cardiac nerve terminals proved to be a sharp aide to clinch this notoriously difficult diagnosis.
Studies find that a drug in cough syrup can improve symptoms, and that radiation therapy safely shuts off a salivary gland.
Researchers will follow former football players at risk for the disorder to identify the best biomarkers and clinical criteria.
At a DLB meeting, scientists reported progress in disentangling the notorious overlap in symptoms and pathology in this quintessential spectrum disease. (Hint: tangles are bad.)