Does TDP-43 Oligomerize and Coax Aβ to Do the Same?
Protein oligomers may be to blame in TDP-43 proteinopathies, as in other neurodegenerative conditions.
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Protein oligomers may be to blame in TDP-43 proteinopathies, as in other neurodegenerative conditions.
Older people who complain of memory problems are more likely to become measurably impaired and to have Alzheimer’s pathology in the brain, especially if they smoke or carry an ApoE4 allele.
MGH meeting traces arc of scientific discoveries from 1980s to today’s cutting edge.
At Birthday Symposium, Massachusetts ADRC Looks to Future With New Data As the first five of the nation’s 27 Alzheimer’s Disease Research Centers system marked their 30th birthday, one of them celebrated with a scientific conference at Massachusetts Gener
In mouse models, removing this growth factor only from immune cells worsened pathology and memory.
A new assay detects tau and α-synuclein seeds in human brain samples. Could it become a diagnostic?
A study claims that two genetic variants combined may hasten cognitive decline in people who have Aβ deposits in the brain.
The pharma giant puts up funding to help develop AstraZeneca’s inhibitor, the second such compound to enter Phase 2 testing.
ALS-linked optineurin works closely with Parkinson’s-associated Pink1 and parkin in a pathway that recycles mitochondria.
Results suggest the drug boosts cognition when given alongside the acetylcholinesterase inhibitor.
Therapeutics that target γ-secretase produced different results in human neurons and mouse models of Alzheimer’s disease.
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