Brain of Woman Who Died on Leqembi Shows Worst-Case Scenario
The patient, an APOE4 homozygote with severe cerebral amyloid angiopathy, developed vascular inflammation and bleeding throughout her brain.
6397 RESULTS
Sort By:
The patient, an APOE4 homozygote with severe cerebral amyloid angiopathy, developed vascular inflammation and bleeding throughout her brain.
Growth-associated protein 43 in the CSF identified people who accumulated tangles fastest. These spread through connected brain regions.
In CD8+ T cells and monocytes, DNA was more accessible in people with AD and even more so in ApoE4 carriers.
ApoE2 reported as raising risk for progressive supranuclear palsy, a rare tauopathy.
Collaborative research directed by Floyd E. Bloom of Neurome Inc. and the Scripps Research Institute shows that dramatic changes occur in the brains of mice expressing mutant human forms of AβPP long before any Aβ has been deposited...
Researchers working on NSAIDs as potential treatments for AD are discussing whether a large ongoing prevention trial of two such anti-inflammatories is testing the right drugs.
The drug memantine can benefit patients with moderate to severe Alzheimer's disease, according to a study reported in the April 3 New England Journal of Medicine...
For several years now, the Alzheimer's research and treatment communities have been awaiting the fruition of promising research into quantitative imaging agents that could signal the presence of amyloid...
In Alzheimer and some other neurodegenerative diseases, the microtubule-associated protein tau weaves a web of neurofibrillary tangles (NFTs) that might...
Depending on how you slice the epidemiological pie, the use of cholesterol-lowering statins could appear to...
The tumor suppressor and apoptotic transcription factor p53 has been linked to Alzheimer disease in numerous ways, but perhaps the most direct link is...
The first rule of triage is do no harm, but try telling that to microglia...
The vascular hypothesis of Alzheimer disease suggests that pathology starts with hypoperfusion, or decreased blood flow to the brain...
A comprehensive proposal of new diagnostic criteria marked a highlight at the International Conference on Alzheimer’s Disease...
For the first time, a paper details a molecular mechanism that links tau to Aβ toxicity at the synapse...