New Microglial Model May Aid Genetic Studies, Drug Screening
Microglia-like cells from blood monocytes facilitate large-scale studies.
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Microglia-like cells from blood monocytes facilitate large-scale studies.
Initial report touted positive exploratory results for nelotanserin, but a correction wiped out optimism.
Using whole-genome sequence analysis, researchers find genetic variants linked to white-matter integrity, and cerebral and hippocampal volume.
In ADNI, only a handful of variants associate with amyloid PET. Their impact may vary by disease stage.
In AIBL, memory declines as people with brain amyloid age. Without amyloid, episodic memory keeps steady, even in ApoE4 carriers.
Knocking down these capillary-hugging cells triggers a domino effect; blood proteins invade the brain, white matter deteriorates, and neurons die.
Researchers improve word recall by jolting the lateral temporal cortex, claiming this counters firing patterns linked to poor memorization.
Newly found labile cross-β filament structures may mediate multivalent protein interactions among low-complexity domains.
Its Challenge Network seeks to attract new investigators and new ideas to focus on cross-disease cell biology.
First presented at CTAD 2017, results suggest good safety, hint at efficacy for this serotonin-targeted drug.
A variant squelching expression of PAD4 enzyme reportedly drives up ALS risk by reducing aggregation of RNA-binding proteins.
Health records from 31 million French people suggest that drinking to excess is a major risk factor for early onset dementia.
Scientists found FUS interacts with Argonaute, miRNAs, and targets mRNAs to quell gene expression.
Ionis Pharmaceuticals reported positive top-line data from the Phase 1/2a trial of its ASO.
World’s biggest brain research award goes to European leaders on Aβ tau and TREM2.