President Proposes Massive Cut to NIH; Potential Fallout for Alzheimer’s Unclear
The proposed budget would strike a blow to biomedical research, and science in general.
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The proposed budget would strike a blow to biomedical research, and science in general.
Route to toxicity converges with RNA binding proteins in membrane-less organelles.
A report claims that in the U.K. dementia research grew substantially since 2008, but more gains are needed to find treatments.
Antibodies against tau lower APP expression and degrade Aβ plaques in transgenic mice.
Although shorter tau peptides formed fibrils in a dish, the R3 domain of tau seeded aggregation in cells.
By virtue of its heavy hydrogen, deutetrabenazine resists metabolism by liver enzymes, allowing clinicians to better titrate the drug.
Prospective study links cardiovascular risk factors to brain amyloid.
In the field’s march toward automated testing, scientists for the first time used biomarker cutoffs determined in one cohort to predict amyloid accumulation in a second. It worked.
In tauopathy mice, ApoE4 hastened neuroinflammation and neurodegeneration. No amyloid involved. (Tip: Think A1 astrocytes.)
Next-Generation Tau PET Tracers Strut Their Stuff Are CSF Assays Finally Ready for Prime Time? ApoE and Tau: Unholy Alliance Spawns Neurodegeneration New Evidence Confirms TREM2 Binds Aβ, Drives Protective Response Location, Conformation, Decoration: Tau
The receptor responds to brain insults such as oligomeric Aβ and cellular debris by jolting microglia into clean-up mode, according to researchers at AD/PD 2017.
TIMP2 and possibly other human plasma proteins reinvigorate aged hippocampi in mice.
For their work on modifiable dementia risk factors and dementia in the oldest old, respectively, Kristine Yaffe and Claudia Kawas split this year’s coveted award in neurodegeneration research.
Need another reason to grab water instead of a soda? Beverages with added sugar—natural or artificial—are linked to smaller brain volume, worse memory, and tripled odds of stroke and dementia.
Showcasing forays into the biology of tau, researchers at AD/PD reported news on tau’s transcriptional regulation, its bungling of synaptic vesicles, its sway over the epigenome, and even flashed an atomic structure.