Natural History Studies Provide Foundation for FTD Research
At ICFTD in Sydney, researchers update the community on ARTFL/LEFFTDS.
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Tracking Onset and Progression of Frontotemporal Dementia
New scales debuted at ICFTD could help clinical trials.
For the Faint of Heart: Doc, Want to Check Their NfL?
What's the use of measuring neurofilament light in blood? The marker could help with AD trial enrollment and measuring drug effects. It could even guide brain-sparing improvements in heart surgery, say researchers at AAIC 18.
At CTAD, Tau PET Emerges as Favored Outcome Biomarker for Trials
Tau’s apparent lockstep with cognitive decline dominated the PET conversation. Piramal flaunted data, and Merck/Cerveau are close behind. A first stab at imaging synapses in the hippocampus drew notice, too.
Neurofilament Light: A Universal Mark of Neurodegeneration
In patients across a range of neurodegenerative diseases, NfL ramps up in the cerebrospinal fluid. Levels are higher in those with worse disease.
First Round of Awards from Chan Zuckerberg Initiative Announced
The awards total $52 million, divided among 17 early career investigators and nine collaborative science teams.
International Conference on Frontotemporal Dementia 2018
11th ICFTD Meeting in Sydney Sorts Out Clinical Subtypes Natural History Studies Provide Foundation for FTD Research Tracking Onset and Progression of Frontotemporal Dementia A Proteomics Dive into Cause of Frontotemporal Dementia Encompassing more than ...
Pig Model of ALS Mimics Human Disease
Swine that express mutated human SOD1 exhibit the hallmarks of ALS pathology, including aggregates and degeneration in motor neurons, preceded by a lengthy preclinical phase.
How Immune Cells From Blood Beget Aging in Brain
At SfN, some scientists described how circulating immune cells deliver aging to the mouse hippocampus; others held off parkinsonism by blocking the effects of eotaxin’s rise in blood. Human trials are starting.
How Does The NIA-AA Framework Measure Up Against Real Data?
Researchers are applying the proposed 2018 NIA-AA diagnostic criteria to three large, standing cohorts. How did the research framework perform?
World Dementia Council Takes Stock of Progress, Challenges
Five years after its creation, the WDC met in London to reflect, articulate next steps, and announce more sharing of BACE trial data.
Toxic Tau: Who Are You, and Where Are You From?
Recent conferences revealed that tau is most toxic in oligomeric form, that tau oligomers propagate throughout the brain, and that tau oligomers might harm synapses from within or via astrocytes.
Society for Neuroscience Annual Meeting 2018
Toxic Stew of Aβ Dimers Hides Out in Human Plaques How Immune Cells From Blood Beget Aging in Brain Toxic Tau: Who Are You, and Where Are You From? Tau Silences, Aβ Inflames; Hitting Excitatory Synapses Hardest When Glial Clocks Fall Out of Sync, ...
When Glial Clocks Fall Out of Sync, Inflammation Ensues
Disrupting circadian clocks in astrocytes and microglia unleashed harmful responses in these glial cells, leading to neuronal damage.
Stem Cell Model Nails Link Between Tauopathy and GABAergic Dysfunction
By marrying iPSCs, human genomic data, and analysis of postmortem tissue, researchers tied loss of GABAergic signaling to tauopathies such as FTD and PSP, but not AD.
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