Keystone: Death Receptor Ligand—New Role for APP, New Model for AD? PAPER RETRACTED.
At the Keystone symposium on Wednesday, debate on the last plenary talk continued around the dinner table and well into the poster session...
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At the Keystone symposium on Wednesday, debate on the last plenary talk continued around the dinner table and well into the poster session...
Protein networks unseen in RNA data correlated closely with plaques, tangles, cognitive decline. Many are in the extracellular matrix.
A curated panel of 48 proteins foretold cognitive decline. It also illuminated biological pathways involved in Alzheimer's disease.
In this month’s Brain, researchers at the Universities of Milan and Genoa, Italy, report that immunizing C57/Bl6 mice with Aβ42 generated an inflammatory response similar to an autoimmune disease in the brains of these mice...
In tomorrow's Nature Medicine, Bruce Yankner at Children's Hospital in Boston offers up a partial explanation for one of the abiding questions in Parkinson's research: Why do neurons die in such a selective pattern?...
Despite its long and distinguished history in Alzheimer’s research, the microtubule-stabilizing protein tau still poses many a riddle to scientists. They do know that excessive phosphorylation of tau somehow figures in neurodegeneration...
randomized trial to test the feasibility of using the COX-2 inhibitor nimesulide as a chronic treatment in Alzheimer's patients...
The job description of presenilins (PS) in the business of neuron health and disease may be getting more complicated...
When it works properly, the endoplasmic reticulum (ER) constantly pumps out newly synthesized membrane proteins, perfectly folded and sorted to their proper cellular destination...
In today's SciencExpress, researchers from Italy, France, and The Netherlands report that mutations in DJ-1, a protein of unknown function, can lead to Parkinson's disease...
The amyloid-β (Aβ) peptide is a destroyer of synapses, and its attack on neurotransmission is blamed for devastating...
The epidemiologic link between elevated blood homocysteine (HC) and Alzheimer disease has spurred the search for the mechanisms by which...
A trend is afoot in Alzheimer disease research that is both potentially alarming and hopeful...
Researchers propose that several-fold increases of α-synuclein can trigger a slew of pathological changes leading to synaptic dysfunction...
Alzheimer imaging aficionados gathered for a peek at the latest data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)...