Spine Shrinkers: Aβ Oligomers Caught in the Act
Though it’s now widely accepted that amyloid-β oligomers are bad news for dendritic spines, most of the data supporting this contention comes from cell culture or tissue slice experiments...
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Though it’s now widely accepted that amyloid-β oligomers are bad news for dendritic spines, most of the data supporting this contention comes from cell culture or tissue slice experiments...
One of the enduring mysteries of Parkinson disease has been the exquisite specificity of neuronal death...
The development of neurotrophic factors for treatment of Alzheimer disease (AD) and other neurodegenerative disorders has proceeded in fits and starts, in no small part due to...
Two studies indicate that the amyloid deposits found in the hippocampus may come not so much from local cells but arrive via the axons of distant neurons projecting there...
Clinical and genetic data have linked Parkinson’s and other synucleinopathies to Gaucher’s disease...
A case report in the December 5 issue of the New England Journal of Medicine presents an example of the potential dangers of anticholinergic drugs in some patients: short-term memory loss and hallucinations...
Presenilins deliver the final cut to unleash the Aβ peptides that form the amyloid plaques that gum up the brains of Alzheimer disease patients...
When told what to kill, the complement system deftly deals the final blows...
Drugs called cholinesterase inhibitors have shown modest benefits for patients with mild to moderate Alzheimer's. In the February Annals of Neurology, researchers led by Steven DeKosky challenge the prevailing theory of how these drugs work...
The tiny fruit fly <em>Drosophila</em> has served researchers well to unravel the function of genes linked to neurodegeneration in Parkinson disease...
The Aβ42 peptide may self-aggregate to form fibers with a structure profoundly different from those made of its less pathogenic cousin Aβ40...
The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients...
The first day of the year is a time for personal reflection...
Last year Deborah Blacker, Rudolph Tanzi and their colleagues reported finding a strong association between a deletion of exon 18 in the gene for α2 macroglobulin (A2M) and Alzheimer's disease...
In conflict with a number of recent studies, six-year data from the Rotterdam study of aging failed to show a link between dietary fat and risk of dementia. The results are reported in today’s Neurology...