Is Too Much Vitamin B12 a Health Hazard?
When observed over an eight-year period, people with the highest plasma concentrations were more likely to die than people with lower levels.
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Tau2020: Meeting for Tauopathies Debuts Genetic Variants
By engaging scientists studying every tau-based disorder, a new conference aimed to foster collaborations and research directions.
Human Amyloid Imaging 2020
PET Tracer Detects Synapse Loss Across Alzheimer’s Brain Multimodal Imaging of Neurodegenerative Diseases Links Pathology and Cellular Dysfunction Tau PET: The Field Expands Rapidly Can PET Match Up Areas of Protein Deposit With Alzheimer’s Symptoms? How ...
Truly New to Déjà Vu: For Five Hopefuls, Lights Go Out After Phase 2
At CTAD, a handful of candidate therapies were reported to have flamed out in Phase 2. They were unable to show efficacy. A new antipsychotic is entering the ring.
Tau2020 Global Conference
Tau2020: Meeting for Tauopathies Debuts Genetic Variants Behold the First Human α-Synuclein CryoEM Fibril Structure New at Tau2020: PET Detects First Traces of Tangles in Rhinal Cortex Primary Tauopathies Get New PET Ligands Tau Receptor Identified on ...
Paper Alert: Mouse TREM2 Antibody Boosts Microglial Plaque Clean-Up
The monoclonal antibody activated TREM2 signaling on mouse microglia. It supported their survival and stimulated their clearance of amyloid plaques.
ALS-like Symptoms in HIV-infected Patients Reversed by Retroviral Therapies
Researchers have suspected retroviruses to play a role in amyotrophic lateral sclerosis (ALS) since the 1960s, when poliomyelitis was proposed to contribute to progression of the disease...
Genetic Wild West: 23andMe Raw Data Contains 75 Alzheimer’s Mutations
23andMe sells people information about their Alzheimer’s and Parkinson’s risk. They include tricky-to-interpret raw data on dozens of disease genes. Should such direct-to-consumer testing companies offer better counselling and referral?
Treating Tau: Finally, Clinical Candidates Are Stepping into the Ring
Three anti-tau antibodies are in Phase 1 or 2, while an O-GlcNAcase inhibitor got the green light to start testing.
Off-Balance Endocytosis Lays Groundwork for Disease
By aging cultured neurons and manipulating them to stimulate endocytosis or interfere with vesicle release, researchers can bring about characteristics of Alzheimer’s—without adding APP or Aβ.
Alzheimer’s GWAS Hits Point to Endosomes, Synapses
Scientists at SfN offer alternate views of Bin1 biology.
A Delicate Frontier: Human Microglia Focus of Attention at Keystone
Working with human microglia is fraught with technical challenges, but that didn’t stop researchers at Keystone from sharing a flurry of data on how these cells act in neurodegenerative disease.
New at Tau2020: PET Detects First Traces of Tangles in Rhinal Cortex
Not sure where that is? You are not alone. It is a tiny spot deep behind the nose, newly defined by the PET signal of early neurofibrillary tangle deposition. It also prompted a tau-staging scheme.
Dementia Research Institute to Double U.K. Coronavirus Testing
United Kingdom’s DRI pivots to fight COVID-19. The facility could test 10,000 samples per day.
Primary Care Physicians Unprepared to Handle Future Alzheimer’s Case Loads
A survey conducted by the Alzheimer’s Association finds that three-quarters of these physicians had little to no residency training in dementia care.
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