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Preimplantation Genetic Diagnosis: A Family Choice

For families with autosomal-dominant neurological conditions, the fear of passing on the disease to their children looms large. Now, people at this highest genetic risk can ensure that they have healthy children by undergoing in vitro fertilization ...

The Mega-Appeal of Nanomedicine

The European Union is banking on big returns from nanotechnology in the fight against AD. European Union Throws Megabucks at Nanomedicine EU Consortium Applies Nanotechnology to Study AD ...

Task Force Focuses on Tracing Brain Amyloid

Online training for use of Amyvid, the first FDA-approved Aβ imaging ligand, is now up and running,even as a task force convened by the Society of Nuclear Medicine and the Alzheimer's Association scrambles to formulate some expert guidelines on how ...

AD Biomarker Labs Can Get Standard Protocol, Quality Control

Did you know that if you had a spinal tap for a cerebrospinal fluid-based Alzheimer's diagnosis in Boston, Stockholm, London, or San Diego, the readout would likely be different in each place? And different again this year and next? That's a ...

Modern Microscopy

Modern Microscopy Skims Surface of Living Minds and Spines Modern Microscopy Plumbs the Depths of Brain Tissue ...

Michael J. Fox Foundation Launches Big PD Biomarker Study

A $40 million multicenter biomarker study for Parkinson disease progression is off and running, with enrollment underway at 10 of 18 sites in the U.S. and Europe. In design and operation, the  Parkinson's Progression Markers Initiative  (PPMI) ...

Medical Foods for Alzheimer's: Palatable Therapy or Snake Oil?

In the absence of truly effective treatments, and in the presence of a rapidly growing, dementia-prone population of elders, it's perhaps no surprise that people are increasingly open to products claiming even the slightest hint of promise, however ...

Metabolomics Comes of Age

Move over, genome, transcriptome, proteome. The latest ome aims to map every metabolite linked to human health and disease. Metabolomics, although still a nascent field, offers hope for biomarkers and treatments in neurodegenerative disease. The field& ...

Will Technology Revolutionize Dementia Diagnosis and Care?

As populations age worldwide and the number of people with dementia is set to soar over the next few decades, a crisis in eldercare looms. At the same time, the use of personal technology—smartphones, tablets, wearable monitors—is exploding. Can ...

Cortical Hubs to Rich Clubs—Linking Brain Connectivity to Function

If you find it hard to keep up with Facebook, LinkedIn, and other social networks, spare a thought for the brain. With 100 to 500 trillion synaptic connections, the human brain dwarfs all of them. How do those connections work to formulate thought, recall ...

Learn the Skinny on iPS Cells in Neurodegenerative Disease

Are you curious about trying iPS cell lines to model the disease you care about? Intrigued but nebulous on where the field is at? Ready to grow an iPS line but not sure where to turn? Read Madolyn Rogers's four-part series to learn all about who does ...

CRISPR: A New Tool For Gene Editors

CRISPR Gene Editing—Poised to Revolutionize Neuroscience? Neuroscientists Probe CRISPR Transgenics and Treatment Paradigms ...

Update on DIAN, API, A4: All About Biomarkers, Trials, and Funds

Alzforum readers who follow the science of preclinical Alzheimer's and prevention may have heard about three independent but complementary programs that together are laying the groundwork for secondary prevention trials across the spectrum of rare to ...

A Contentious Hypothesis About Where and How PD Starts

A contentious hypothesis about where and how Parkinson’s disease starts off is gaining ground as new studies provide clues in its support. Neuroanatomists Heiko Braak and Kelly Del Tredici, both at the University of Ulm in Germany, have described the ...

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