Protecting Proteasomes from Toxic Tau Keeps Mice Sharp
In transgenic mice, revving up proteasome function lowered tau deposits and improved memory.
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Cancer Drug Clears Plaque, Improves Mouse Memory
An immunotherapy drug recruits immune cells to the brain, where they help clean up amyloid plaques.
Replication a Challenge in Quest for Alzheimer’s Blood Test
Researchers failed to confirm a high-profile, previous 10-lipid panel, but remain bullish on the potential of blood-based metabolites as biomarkers.
It’s All in the Packaging: Better Delivery Renders HDAC Combo Effective in Mice
Caging an HDAC inhibitor in a lipid chelator raised plasma and brain concentrations of the drug and doubled the lifespan of a mouse model of Niemann-Pick type C disease.
Mexiletine Banishes Muscle Cramps in Phase 2 Trial of ALS
Scientists wonder if the sodium channel blocker might also slow disease progression.
Acetylated Tau Mucks Up Memories
The modified protein prevents the synaptic protein KIBRA from managing plasticity.
Can’t Degrade That Pesky Misfolded Protein? Push It Off the MAPS
Not exosome, not proteasome, not autophagy: Could a new pathway dubbed MAPS facilitate the spread of amyloidogenic proteins?
In First Phase 3 Trial, the Tau Drug LMTM Did Not Work. Period.
Claims of a positive effect in a small subgroup of patients are statistically meaningless, experts say.
Paper Alert: Aducanumab Phase 1b Study Published
The monoclonal antibody appears to remove plaques, although the small trial could not draw conclusions about cognition.
Immune Receptor May Smuggle α-Synuclein into Neurons, Hasten Proteopathy
The LAG3 transmembrane protein latches onto fibrillar forms of the synaptic protein and ushers them into neurons. Researchers propose targeting LAG3 to slow toxic spread of misfolded forms of synuclein.
Once Again, Statins Found to Reduce Alzheimer’s Risk
Despite conflicting results in the past, a large new study analyzing multiple statins in different ethnic groups suggests a protective effect from this class of medication.
Transport Breakdown Maroons BACE1 in Synapses, Boosts Aβ
Restoring normal transport of BACE1-carrying endosomes prevents synapse loss and cognitive decline in mice.
From Garbage Disposal to Neuromodulation? Membrane Proteasomes Churn Out Stimulating Peptides
In a bizarre twist of cell biology, researchers find proteasomes in the neuronal plasma membrane. They pump signaling peptides into the extracellular space.
Finally, a Dye to Visualize Pericyte Function
A new fluorescent compound labels only non-contractile cells in the capillary bed, supporting the idea that these mysterious little cells do not directly regulate brain blood flow.
Do Perivascular Macrophages Mediate Aβ Pathology?
Researchers implicate these innate immune cells in the disruption of neurovascular coupling by Aβ in mice.
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