ABCA1 Loss Lowers ApoE, Not Amyloid; New ApoE Immunology
A foursome of papers on ApoE deserves attention this week. Having plenty of ApoE is a prerequisite for...
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A Blood Test for AD?
Plasma cholesterol measurements have done wonders for cardiovascular disease management...
One Thumb Up on Dietary Fat, One Down on Vitamins, Two Down on Estrogen
A foursome of papers in the February 17 Archives of Neurology continues the shifting debates about three epidemiological questions in Alzheimer’s research...
Popcorn Plaque? Alzheimer Disease Is Slow, Yet Plaque Growth Is Fast
Thanks to a new imaging technology, researchers discovered that amyloid plaques can literally show up overnight and grow to their full size in just a few days...
Spine Shrinkers: Aβ Oligomers Caught in the Act
Though it’s now widely accepted that amyloid-β oligomers are bad news for dendritic spines, most of the data supporting this contention comes from cell culture or tissue slice experiments...
Multiple Hits Explain Selective Loss of Dopamine Neurons in PD
One of the enduring mysteries of Parkinson disease has been the exquisite specificity of neuronal death...
Special Delivery: NGF Trial Puts Growth Factor Where It’s Needed
The development of neurotrophic factors for treatment of Alzheimer disease (AD) and other neurodegenerative disorders has proceeded in fits and starts, in no small part due to...
Can Travel, Will Deposit: Aβ via the Perforant Pathway?
Two studies indicate that the amyloid deposits found in the hippocampus may come not so much from local cells but arrive via the axons of distant neurons projecting there...
Feedback Loop—Molecular Mechanism for PD, Gaucher’s Connection
Clinical and genetic data have linked Parkinson’s and other synucleinopathies to Gaucher’s disease...
The Quality-of-Life Balance: Anticholinergics in the Hot Seat
A case report in the December 5 issue of the New England Journal of Medicine presents an example of the potential dangers of anticholinergic drugs in some patients: short-term memory loss and hallucinations...
Perpetrator and Savior—Presenilins Cut Both Ways
Presenilins deliver the final cut to unleash the Aβ peptides that form the amyloid plaques that gum up the brains of Alzheimer disease patients...
Revise Mechanism for Alzheimer's Drug? Acetylcholine Increased in Earliest Stage of Disease
Drugs called cholinesterase inhibitors have shown modest benefits for patients with mild to moderate Alzheimer's. In the February Annals of Neurology, researchers led by Steven DeKosky challenge the prevailing theory of how these drugs work...
Parkinson Pathways Branch Out in Flies and Mice
The tiny fruit fly <em>Drosophila</em> has served researchers well to unravel the function of genes linked to neurodegeneration in Parkinson disease...
CryoEM Exposes Possible Achilles’ Heel in Aβ1-42 Fibrils
The Aβ42 peptide may self-aggregate to form fibers with a structure profoundly different from those made of its less pathogenic cousin Aβ40...
Schizophrenia Drugs Said to Raise Stroke Risk in Dementia Patients
The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients...
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