Microtubule Regulator Connects TDP-43 to Axonal Dysfunction
Two independent studies find that loss of nuclear TDP-43 leads to mis-splicing of stathmin 2, an essential protein for axon growth and repair.
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Rogue Gene Networks Track with Neurodegeneration Across Diseases
Aberrant gene-expression patterns found to be common to human neurodegenerative disease and animal models. MicroRNA and epigenetic modification may be to blame.
Cut Loose, Soluble TREM2 Beckons Microglia to Mop Up Plaques
Boosting sTREM2 in the brain rallied microglia to clear Aβ plaques, restored synaptic plasticity, and even rescued memory deficits in mice.
Tau Aggregates Awaken Genetic Relics in the Brain
By prying open chromatin, neurofibrillary tau may expose dormant transposable elements for transcription.
Microglial Master Regulator Tunes AD Risk Gene Expression, Age of Onset
The discovery hints that microglia, rather than neurons, may control much of a person’s genetic susceptibility to Alzheimer’s disease.
Aβ Acts Through Pericytes to Throttle Brain Blood Flow
In response to the peptide, these little cells squeeze capillaries, constricting them. This may contribute to neuronal dysfunction.
New PET Staging Scheme for Amyloid?
Longitudinal data identifies four stages of amyloid plaque buildup, with the earliest deposits appearing in the precuneus and posterior cingulate.
Cognitive Decline Trips Up API Trials of BACE Inhibitor
Co-sponsors Banner, Novartis, and Amgen announced that they will stop testing CNP520 in two Phase 2/3 studies in people at risk of AD. The drug worsened cognition.
In Alzheimer’s, More TREM2 Is Good for You
Longitudinal ADNI data tie higher sTREM2 in CSF to slower cognitive decline, reinforcing the idea that TREM2 activity protects the brain from AD pathology.
Blood Pressure: How Low to Prevent Dementia—and When?
Hypertension in people as young as the mid-30s can predict late-life cerebrovascular disease and brain shrinkage. Intensive reduction of blood pressure can prevent the damage, but not when given in late life.
End of the BACE Inhibitors? Elenbecestat Trials Halted Amid Safety Concerns
Biogen and Eisai announced the discontinuation of the Phase 3 program. Elenbecestat was the only remaining BACE inhibitor being tested for AD.
Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
The same endothelial cell response is found in various models of brain disease.
To Monitor Neurons, Microglia Talk With the Boss, aka the Soma
Prior research has focused on microglia interacting with synapses. New data show they also deal directly with the neuronal cell body. Like little conference rooms, specialized junctions host this communication.
Does Tau Kill Neurons by Way of Necroptosis?
In Alzheimer’s brain, granulovacuolar bodies in neurons harbor activated necrosomes. They correlate with tau pathology and neuron loss, raising new questions about how neurons die in this disease.
Newly Identified Microglia Contain Lipid Droplets, Harm Brain
These cells accumulate in old mouse and human hippocampi, as well as in a mouse model of neurodegenerative disease.
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