Everyone knows that smoking is bad for you. But there is some evidence, both epidemiological and molecular, that smokers are at reduced risk for neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD)...
A behavioral intervention slowed memory slippage and functional decline over two years.
Analysis of MRI brain volume data identifies multiple AD and FTD/ALS disease subtypes with distinct patterns of degeneration over time.
A small molecule that protects neurons fends off a short region of Aβ from a specific pocket on the LilrB2 receptor.
Profile matches Braak staging regions, suggesting those areas are particularly susceptible to AD pathology.
In DIAN, participants who are more physically active may also have slower disease progression.
In several model systems, α-synuclein boosts oleic acid production and the fatty acid worsens α-synuclein pathology.
In presynapses, binding sequesters synaptic vesicles.
The first rule of triage is do no harm, but try telling that to microglia...
Rare mutations in a microglial receptor contribute as much to Alzheimer’s risk as does the more common ApoE4 genotype...
When told what to kill, the complement system deftly deals the final blows...
Scientists report that astrocytes help neurons destroy their unwanted mitochondria.
Animal models suggest excessive NFκB-TNFα signaling brings on compulsive behavior in a frontotemporal dementia mouse model and early death in flies.
Microfluidic tri-culture of neurons, astrocytes, and microglia models how glia impose deadly neuroinflammation on top of amyloid and tau pathology.
Two independent studies find that loss of nuclear TDP-43 leads to mis-splicing of stathmin 2, an essential protein for axon growth and repair.