Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions?
Data on ASOs, presented recently at the annual meeting of the American Academy of Neurology, depict RNA-based therapies as broadly on the rise in neurodegenerative diseases.
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Adding ALS to the Manifestations of VCP Mutations
In hunting for mutations that cause ALS, researchers discovered that VCP mutations, long thought to spare the spine, are instead a cause of inherited ALS...
Which Cell Types Execute Your Genetic Risk? For AD and PD, Scientists Know.
For several neurodegenerative diseases, scientists identified which cell types exert a person’s inherited risk. In Alzheimer’s, it’s microglia; in Parkinson’s, it’s dopaminergic and enteric neurons—and oligodendrocytes.
Studies Reveal New Hope, Old Problems With AD Biomarkers
Brain imaging and cognitive tests may be the gold standards for tracking AD progression, but clinical trials using these procedures are expensive, risky, and time-consuming...
Stem Cells Reveal Mechanism Behind Alzheimer’s Risk Factor
Risk alleles of SORL1 dampen its expression in response to growth factors, leading to higher Aβ production.
Voilà SorLA! Sorting Receptor’s Structure Solved
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
SORLA Serves Up Aβ for Destruction
It’s not just for tugging APP around the neuron: The SORLA receptor may also bind Aβ and hasten its demise.
New Genetic Insights Into AD: SORL1 and Natural Selection
Two papers published this month claim to identify those at greatest risk for Alzheimer’s disease and illuminate the mechanisms behind it...
Keystone: Probing the Function of Lipoprotein and Related Receptors
Scientists are discovering just how intimately involved lipoprotein receptors are in the care and maintenance of neurons and their synapses...
Sorting Progranulin With Sortilin—New Clues to FTLD Pathology
Progranulin, a raw form of granulin (GRN), landed center stage of neurodegeneration research four years ago...
Aβ and SORLA—Partners in Cerebrovascular Crime?
For years there has been a somewhat murky connection between Alzheimer disease and cerebrovascular disease...
Sorting Out SorLA—What Role in APP Processing, AD?
The sorting receptor SorLA is thought to...
AD Genetics—Problems and Promise
The completion of the human genome sequence brought renewed hope that genetic causes and susceptibilities to disease could be identified...
Paper Alert: SorLa and APP
This week, a study previously reported in our Conference News appeared in PNAS. In it...
Parkinson's Therapies Seek to Stem Progression
Trialists are shooting new arrows at the disease, including compounds that tweak autophagy, neuroinflammation, and glycolipid recycling.
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