Studies Reveal New Hope, Old Problems With AD Biomarkers
Brain imaging and cognitive tests may be the gold standards for tracking AD progression, but clinical trials using these procedures are expensive, risky, and time-consuming...
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Stem Cells Reveal Mechanism Behind Alzheimer’s Risk Factor
Risk alleles of SORL1 dampen its expression in response to growth factors, leading to higher Aβ production.
Voilà SorLA! Sorting Receptor’s Structure Solved
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
SORLA Serves Up Aβ for Destruction
It’s not just for tugging APP around the neuron: The SORLA receptor may also bind Aβ and hasten its demise.
New Genetic Insights Into AD: SORL1 and Natural Selection
Two papers published this month claim to identify those at greatest risk for Alzheimer’s disease and illuminate the mechanisms behind it...
Keystone: Probing the Function of Lipoprotein and Related Receptors
Scientists are discovering just how intimately involved lipoprotein receptors are in the care and maintenance of neurons and their synapses...
Sorting Progranulin With Sortilin—New Clues to FTLD Pathology
Progranulin, a raw form of granulin (GRN), landed center stage of neurodegeneration research four years ago...
Aβ and SORLA—Partners in Cerebrovascular Crime?
For years there has been a somewhat murky connection between Alzheimer disease and cerebrovascular disease...
Sorting Out SorLA—What Role in APP Processing, AD?
The sorting receptor SorLA is thought to...
AD Genetics—Problems and Promise
The completion of the human genome sequence brought renewed hope that genetic causes and susceptibilities to disease could be identified...
Paper Alert: SorLa and APP
This week, a study previously reported in our Conference News appeared in PNAS. In it...
Parkinson's Therapies Seek to Stem Progression
Trialists are shooting new arrows at the disease, including compounds that tweak autophagy, neuroinflammation, and glycolipid recycling.
Beware That Toast: Gluten Sensitivity in Some People with ALS?
In a preliminary study, 15 percent of people with ALS had antibodies against an enzyme that processes the wheat protein gluten.
Alzheimer's Disease Research Summit 2015: Expanding the Horizon
At an NIH conference in Washington, D.C., experts from beyond Alzheimer’s research discussed ways to beef up data collection and patient participation.
Herpesvirus: Trigger for Many Brain Pathologies?
At Quebec conference, researchers considered multiple aspects of herpesvirus biology that may come in to play in AD.
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