Amplitude Modulation—Do MicroRNAs Muffle Noise in Gene Expression?
By dampening translation, these tiny RNAs keep protein levels from fluctuating wildly.
6400 RESULTS
Sort By:
By dampening translation, these tiny RNAs keep protein levels from fluctuating wildly.
The highs and lows of cerebrospinal fluid Aβ and PET amyloid imaging don't necessarily agree.
Peptides made from D-amino acids bind to Aβ oligomers and trigger their removal from the brain. Some appear poised to enter Phase 1.
At the AD/PD conference, researchers reported a protective gene variant that delays Alzheimer’s onset by 10 years, and parsed pathways to find out why particular neurons take the hit in specific diseases.
New data argue that multimers of α-synuclein may protect against pathological aggregation.
Blamed for neurodegeneration and memory problems, the transcription factor ATF4 may also be a gatekeeper for synaptic plasticity and memory formation.
Researchers no longer debate whether misfolded proteins spread through the brain in neurodegenerative disease. Now they want to know how.
Scientists have found that the nuclear receptor ERRγ ramps up mitochondrial energy production in neurons.
Researchers link the AD Risk gene BIN1 to tau and amyloid in different model systems, and propose a mechanism for how a PICALM variant might be protective.
Senataxin, a gene associated with early onset ALS, regulates how cells respond to viruses.
Four new studies call into question PLD3’s status as an AD risk factor. Larger studies may be needed to settle the debate.
In a preliminary study, 15 percent of people with ALS had antibodies against an enzyme that processes the wheat protein gluten.
Deep brain stimulation helps many people with Parkinson’s, but how it does so remains a mystery. A new study suggests it normalizes brain rhythms.
The growth factor turns off microglia, major support cells for neurons.
At AD/PD, researchers further tied TREM2 to phagocytosis and enumerated markers that may distinguish beneficial microglia from harmful ones.