Exercise Linked to Less Pathology, Better Function in Familial AD
In DIAN, participants who are more physically active may also have slower disease progression.
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Does Oleic Acid Hold the Key to α-Synuclein Toxicity?
In several model systems, α-synuclein boosts oleic acid production and the fatty acid worsens α-synuclein pathology.
Secreted APP Binds GABA-B Receptors, Blocks Neurotransmitter Release
In presynapses, binding sequesters synaptic vesicles.
Microglia—Medics or Meddlers in Dementia
The first rule of triage is do no harm, but try telling that to microglia...
Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk
Rare mutations in a microglial receptor contribute as much to Alzheimer’s risk as does the more common ApoE4 genotype...
Complement: AD Friend or Foe? New Work Tips Balance to Former
When told what to kill, the complement system deftly deals the final blows...
Some Neurons Enlist Glia to Take Care of Their Trash
Scientists report that astrocytes help neurons destroy their unwanted mitochondria.
Brain Inflammation Drastically Changes Behavior and Lifespan in Animals
Animal models suggest excessive NFκB-TNFα signaling brings on compulsive behavior in a frontotemporal dementia mouse model and early death in flies.
Invading Microglia Unleash Neurodegeneration in 3D AD Culture
Microfluidic tri-culture of neurons, astrocytes, and microglia models how glia impose deadly neuroinflammation on top of amyloid and tau pathology.
Microtubule Regulator Connects TDP-43 to Axonal Dysfunction
Two independent studies find that loss of nuclear TDP-43 leads to mis-splicing of stathmin 2, an essential protein for axon growth and repair.
Rogue Gene Networks Track with Neurodegeneration Across Diseases
Aberrant gene-expression patterns found to be common to human neurodegenerative disease and animal models. MicroRNA and epigenetic modification may be to blame.
Cut Loose, Soluble TREM2 Beckons Microglia to Mop Up Plaques
Boosting sTREM2 in the brain rallied microglia to clear Aβ plaques, restored synaptic plasticity, and even rescued memory deficits in mice.
Tau Aggregates Awaken Genetic Relics in the Brain
By prying open chromatin, neurofibrillary tau may expose dormant transposable elements for transcription.
Microglial Master Regulator Tunes AD Risk Gene Expression, Age of Onset
The discovery hints that microglia, rather than neurons, may control much of a person’s genetic susceptibility to Alzheimer’s disease.
Aβ Acts Through Pericytes to Throttle Brain Blood Flow
In response to the peptide, these little cells squeeze capillaries, constricting them. This may contribute to neuronal dysfunction.
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