New PET Staging Scheme for Amyloid?
Longitudinal data identifies four stages of amyloid plaque buildup, with the earliest deposits appearing in the precuneus and posterior cingulate.
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Cognitive Decline Trips Up API Trials of BACE Inhibitor
Co-sponsors Banner, Novartis, and Amgen announced that they will stop testing CNP520 in two Phase 2/3 studies in people at risk of AD. The drug worsened cognition.
In Alzheimer’s, More TREM2 Is Good for You
Longitudinal ADNI data tie higher sTREM2 in CSF to slower cognitive decline, reinforcing the idea that TREM2 activity protects the brain from AD pathology.
Blood Pressure: How Low to Prevent Dementia—and When?
Hypertension in people as young as the mid-30s can predict late-life cerebrovascular disease and brain shrinkage. Intensive reduction of blood pressure can prevent the damage, but not when given in late life.
End of the BACE Inhibitors? Elenbecestat Trials Halted Amid Safety Concerns
Biogen and Eisai announced the discontinuation of the Phase 3 program. Elenbecestat was the only remaining BACE inhibitor being tested for AD.
Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
The same endothelial cell response is found in various models of brain disease.
To Monitor Neurons, Microglia Talk With the Boss, aka the Soma
Prior research has focused on microglia interacting with synapses. New data show they also deal directly with the neuronal cell body. Like little conference rooms, specialized junctions host this communication.
Does Tau Kill Neurons by Way of Necroptosis?
In Alzheimer’s brain, granulovacuolar bodies in neurons harbor activated necrosomes. They correlate with tau pathology and neuron loss, raising new questions about how neurons die in this disease.
Newly Identified Microglia Contain Lipid Droplets, Harm Brain
These cells accumulate in old mouse and human hippocampi, as well as in a mouse model of neurodegenerative disease.
Picking Through the Rubble, Field Tries to Salvage BACE Inhibitors
At CTAD, researchers discussed possible paths forward. One option: exploring whether low doses prevent plaque accumulation while avoiding the cognitive side effects.
Single-Cell Expression Atlas Charts Changes in Alzheimer’s Entorhinal Cortex
Specific patterns of expression defined distinct subtypes of neurons, astrocytes, oligodendrocytes, and microglia in this early affected brain region.
Cell-Specific Enhancer Atlas Centers AD Risk in Microglia. Again.
Cataloguing enhancer-promoter interactions in the four major cell types of the brain, researchers found that Alzheimer’s risk variants predominantly appeared in microglial enhancers.
AD Genetic Risk Tied to Changes in Microglial Gene Expression
Functional variants of AD GWAS hits found in enhancers of myeloid genes.
Next-Generation Tau PET Tracers Strut Their Stuff
Emerging data on new tau ligands raise hope of more signal, less noise, and help with a broad range of tauopathies. Read news culled from the AD/PD and HAI 2017 meetings.
Absent Aβ, Blood-Brain Barrier Breakdown Predicts Cognitive Impairment
A leaky blood-brain barrier in the hippocampus correlated with cognitive impairment, independently of other vascular risk factors or Alzheimer’s pathology.
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