AD Clinical Pipeline: Immunotherapy Woes, Dimebon Boons
Two papers in the 19 July Lancet bring both dismay and hope to the ongoing quest for more effective AD treatments...
ALL NEWS
5724 RESULTS
Sort By:
- Most Recent
- Most Commented
BACE and γ-Secretase Form Mega-Complex that Processes APP
Are high-molecular-weight, multi-protease complexes cellular Aβ factories?
AMPA Receptors: Going, Going, Gone in Aβ-exposed Synapses, PSD95 Knockouts
One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that...
SfN: The Old and the New—BACE and Cathepsin B Share the β-secretase Stage
A lively platter of slide talks on APP processing and β-secretase (BACE) activities yielded a few interesting tidbits on the...
Dangerous Liaisons—Tau and Aβ, Together at Last?
They are no match made in heaven, but in neurons, the two proteins responsible for amyloid plaques and neurofibrillary tangles might...
Hot DAM: Specific Microglia Engulf Plaques
The transcriptomes of single immune cells in the mouse brain identify specific disease-associated microglia (DAM), which eat away at Aβ deposits.
Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80
Scientists propose that LATE is a neurodegenerative disease marked by TDP-43 pathology in limbic regions, and memory loss. After death, it can be seen alone or with other pathology.
Do World Trade Center Responders Get Early Onset Plaques and Tangles?
Middle-aged WTC responders have cognitive problems, which correlate not only with their PTSD symptoms and exposure to toxic dust, but also with biomarkers of amyloid and tau.
Plaques, Tangles Throw Off the Brain’s Rhythms
In the human brain, alpha waves fell out of sync, while delta-theta waves swelled in concert with amyloid plaques, neurofibrillary tangles. Alpha modulation correlated with cognitive decline.
Dementia Researchers Commend FDA Crackdown on Supplement Hype
When the agency sent warning letters to 17 companies that falsely advertised cures and preventions for AD, most took down exaggerated claims. But can regulations stay ahead of the market?
Tackling Alzheimer’s from the Outside In
Feeling good on the outside often helps us feel good on the inside. Could the same be true for neurons?...
The Alzheimer's Vaccination Story, Continued
Two papers advance the drive to develop an Alzheimer's vaccine, one looking at the antibody response in some of the Elan trial participants, the other using sophisticated methods to analyze the epitope recognized by antibodies generated in response to Aβ42 immunization.
It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
Researchers induced cortical organoids to grow their own vasculature and even form a blood-“brain” barrier, making the little blobs more useful for studying disease.
Does Second X Chromosome Boost Women’s Resilience Against Alzheimer’s?
In female mice it’s the other X chromosome, not lack of a Y, that extends life and preserves memory in the face of amyloidosis. A histone demethylase gene partly explains this. It protects people, too.
IFITM3 Forges Link Between Neuroinflammation and Aβ Production
The antiviral protein enhances γ-secretase processing of APP. More of it is present in Alzheimer’s disease.
Current Filters
- Date Range : All x