FTD Gene Hunt Turns Up CYLD and Modifying Factors
Geneticists at frontotemporal dementia conference reported a new link with a ubiquitine enzyme and strengthened other gene associations.
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Geneticists at frontotemporal dementia conference reported a new link with a ubiquitine enzyme and strengthened other gene associations.
Sometimes challenged, the idea that pathogenic proteins spread through the brain got a lift from new animal model data presented at the frontotemporal dementia meeting.
Idalopirdine failed to slow memory decline in patients with Alzheimer’s disease.
In mice, rolofylline perks up neurons laid low by aggregates of tau.
Can sucking in a little extra drug tide patients over until their next dose?
The fragment crowds into synapses and may drag full-length tau along for the ride. Researchers proposed caspase-2 as a therapeutic target.
Preserved brain networks may explain the exceptional memory prowess of some older adults.
The mysterious protein made by the ALS/FTD-associated gene may regulate the actin filaments that physically support axons.
Researchers at the Kloster Seeon meeting pressed in on the question of what are the physiological functions of this protease after development is complete.
At 2nd Kloster Seeon Meeting, Renewed Optimism for Targeting BACE1 What Exactly Does BACE Do in Adults? BACE Inhibition and the Synapse—Insights from Seeon Does BACE Drive Neurites into Dystrophy, Shorting Circuits? Will Next-Gen BACE Inhibitors Dodge Sid
At the 2nd Kloster Seeon meeting on BACE proteases, researchers linked BACE substrates to regulation of synaptic activity.
In Seeon, researchers reported that blocking the protease may heal dystrophic neurites and repair electrical activity.
Despite no warning signs in ongoing clinical trials, researchers are searching for safer drugs, and better biomarkers to measure what they do.
In development, the brain follows a set of rules when it folds to form its ridges and grooves. Those rules change with age, and especially in Alzheimer’s.
In Italian memory clinics, the PET scans resulted in diagnosis and medication changes for up to a third of patients.