Parkinson Pathways Branch Out in Flies and Mice
The tiny fruit fly <em>Drosophila</em> has served researchers well to unravel the function of genes linked to neurodegeneration in Parkinson disease...
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CryoEM Exposes Possible Achilles’ Heel in Aβ1-42 Fibrils
The Aβ42 peptide may self-aggregate to form fibers with a structure profoundly different from those made of its less pathogenic cousin Aβ40...
Schizophrenia Drugs Said to Raise Stroke Risk in Dementia Patients
The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients...
Editor’s Dozen: 13 Top AD Trends in 2010
The first day of the year is a time for personal reflection...
The A2M Deletion, Revisited
Last year Deborah Blacker, Rudolph Tanzi and their colleagues reported finding a strong association between a deletion of exon 18 in the gene for α2 macroglobulin (A2M) and Alzheimer's disease...
Rotterdam Study Questions Links between Fat and Dementia Risk
In conflict with a number of recent studies, six-year data from the Rotterdam study of aging failed to show a link between dietary fat and risk of dementia. The results are reported in today’s Neurology...
SUMO-Wrestling with APP?
In the January 7 PNAS, researchers from the biopharmaceutical company Scios Inc. reported that sumoylation, the covalent modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has a dramatic impact on amyloid β production...
Lean Mice Live Longer: Does Insulin in Fat Hasten Aging?
Those who can eat as much as they please without gaining avoirdupois may feel smug about a paper in tomorrow’s Science, which reports that mice that lack insulin receptors only in their fat tissue outlive their normal brethren by about 18 percent...
San Diego: HIV and AD—Save the Body, Lose the Mind?
Drug cocktails have transformed HIV infection from a deadly to a chronic disease, giving HIV carriers a new lease on life. But new long-term consequences...
Coaxing Longevity from Catalase
Mice live longer and show signs of delayed aging when they express the antioxidant enzyme...
Youth Group Promotes Alzheimer’s Research and Support for Elderly
A youth movement promotes awareness of Alzheimer’s disease and elder issues among high school and college students, as well as encourage young people to go into AD research...
‘Godfather of Tau’ Skip Binder Dies at 63
Known for his contributions to the fundamental understanding of the tau protein, Skip Binder leaves his mark on the Alzheimer's field.
PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial
IMAGINE that: Amyloid deposition shrinks in both treatment and placebo groups, dealing a blow to the anti-aggregation drug PBT2.
Could Bolstering the Retromer Thwart Alzheimer’s?
A drug candidate for Alzheimer’s aims to make cell trafficking more efficient, reduce Aβ production.
Has ApoE’s Time Come as a Therapeutic Target?
An antibody against ApoE helps clear plaques and improves cognition in AD model mice.
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