Second Look at BAN2401 Data Still Positive, Despite Snafu
Subgroup analysis addresses APOE4 randomization imbalance, claims treatment with this anti-Aβ protofibril antibody slowed cognitive decline.
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Scientists Hunting Rare Alzheimer’s Mutations Eye Phospholipase D3
Hunting for rare mutations that cause dementia, researchers have spotted, but not yet snagged, some tantalizing candidates.
The Power of Three: Genetic Trios Yield ALS Gene Candidates
The May 26 Nature Neuroscience online debuts 25 new candidate genes for amyotrophic lateral sclerosis...
At AD/PD Conference, New Alzheimer’s Genes Reinforce Known Pathways
After years of grunt work on next-gen sequencing and expression analysis, geneticists are finally reaping results. The new genes underscore the role of known pathways and cell types in disease.
APP Upp: Mutation Nixes Six Amino Acids from Aβ, Spurs Aggregation
Presented at AD/PD, the discovery by scientists in Uppsala is the first APP deletion found to cause Alzheimer’s disease. The same group found the Swedish and Arctic APP mutations.
Older Children with Spinal Muscular Atrophy Improve on Nusinersen
Long-term treatment with the anti-sense oligonucleotide led to motor benefits in an extension trial of children 2 to 15 years old.
New Money to Spur Tech Search for AD Biomarkers
Diagnostics Accelerator to fund projects that develop dementia biomarkers from patient data.
Light Is Alright: Mild Physical Activity Comes With Larger Brain
People who take leisurely walks, garden, and tackle household chores had bigger brains than those who were more sedentary. Vigorous exercise brought neither additional benefit nor harm.
ApoE Has Hand in Alzheimer’s Beyond Aβ, Beyond the Brain
At a Keystone meeting, researchers agreed that ApoE stokes damaging neuroinflammation in response to tau pathology. The E4 allele ramped up cholesterol biosynthesis in microglia and astrocytes, and even promoted neuronal damage when expressed outside of the brain.
Protein Propagation Real, but Mechanisms Hazy
Researchers no longer debate whether misfolded proteins spread through the brain in neurodegenerative disease. Now they want to know how.
Lowering ApoE Brings Down Amyloid in Mice
Apolipoprotein E4 clearly plays a role in AD and could be a therapeutic target, but scientists are not sure whether they should raise or lower it in the brain...
Do Immune Cells Promote the Spread of α-Synuclein Pathology?
At AD/PD 2019, scientists implicated both peripheral and central innate immunity in promoting propagation.
WHO Weighs in With Guidelines for Preventing Dementia
The global agency’s report recommends physical activity, a healthy diet, stopping alcohol abuse and smoking, and managing one’s weight, blood pressure, and diabetes.
Amid Brexhaustion, U.K. DRI Marches On, Seeks Innovation Director
Institute to chart new translational research territory.
C9ORF72 Toxicity Tied to Mitochondria, Transcriptional Machinery
In a new, inducible mouse model, poly(GR) damages mitochondria, but its effect is reversible. In flies, turning off transcription of hexanucleotide expansion protects cells.
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