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Fragments of amyloid-β precursor protein (APP) previously associated with Alzheimer disease pathology are present at dramatically higher levels in the brains of young, perfectly normal adults...
In ALS and other neurodegenerative disorders, a newer player could be joining the current star under the limelight...
The relatively recent realization that neurogenesis is alive and kicking in the adult hippocampus has scientists wondering if the phenomenon can be exploited...
Fundamental knowledge gaps in Alzheimer disease research include a clear grasp of the normal role of the amyloid precursor protein (APP), and the molecular basis for the increased risk for AD as people age...
At this year’s Society for Neuroscience annual meeting, a special ancillary symposium explored the normal and pathological roles of APP...
On the one hand, research studies have amassed a laundry list of factors that influence experimental amyloid deposition in mouse models of amyloidosis...
A major point of confusion in this field has been that different research groups are working with different kinds of Aβ oligomer...
Since they were discovered to be a major toxic species, Aβ oligomers have haunted many a research lab...
Vaccination is not just for amyloid anymore...
Using a new optogenetic model for TDP-43 phase transitions, scientists see the protein aggregate outside, not inside stress granules. The model distinguishes physiological from abnormal phase transition.
Dysfunction of the ubiquitin-proteasome system (UPS)...
Glaucoma and Alzheimer disease (AD) might share more than being chronic, age-related diseases with devastating neurodegeneration...
The basic understanding of Parkinson disease, the second most common neurodegenerative disorder after Alzheimer’s, is...
Since mutations in the PINK1 and DJ-1 genes were found to cause autosomal recessive forms of Parkinson disease...
The human ApoE4 isoform is the biggest single risk factor for sporadic Alzheimer disease (AD)...
