Hormone Replacement Therapy Latest Entry to AlzRisk Database
Despite almost two decades of research, it is not yet clear how hormone replacement therapy affects a woman’s risk of getting Alzheimer’s disease...
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Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque Formation
An article in the February 24 Nature Neuroscience online suggests that amyloid-β (Aβ), the peptide responsible for the intercellular plaques that appear in the brains of Alzheimer's patients, can freely diffuse through neural tissue, and that it plays a major role in the pathogenesis of the disease...
A PD Trifecta: Synuclein Gene Expression, Aging, and Inflammation
A trio of collaborators has unearthed an unlikely regulator of α-synuclein gene (SNCA) expression...
Caught in the Act—Amyloid Damages Neurons
Since Alois Alzheimer’s first descriptions of senile plaques, we have known that they are associated with dementia. But are they detrimental?...
First Crystal Structure of a Presenilin
In this week’s Nature, researchers report the first successful crystal structure of a bacterial presenilin homologue...
Alzheimer’s in a Dish? Aβ Stokes Tau Pathology in Third Dimension
Amyloid plaques and tau tangles sprout in human neuron cultures grown in a supportive gel. Researchers think this system may closely model human disease and aid in drug discovery.
Mutant Presenilin Knock-in Mice Mimic Knockouts, Stir Old Debate
Mice expressing presenilin harboring AD-associated mutations resemble mice lacking the enzyme altogether, suggesting that the mutations fully inactivate the enzyme.
Cerebrospinal Fluid Neurogranin Correlates with Markers of Neurodegeneration
Levels of CSF biomarker neurogranin correlate with imaging measures of synaptic integrity in ADNI cohort.
Lilliputian Effect Size Fells Phase 3 Trial of Solanezumab, Leaving Its Future Uncertain
Eli Lilly has given up on regulatory submission for mild AD, but leaves door open to seeking approval for earlier disease stages if three ongoing studies succeed.
CTAD: Solanezumab Seen to Nudge AD Ever so Slightly
Patients on solanezumab saw small improvements on multiple secondary endpoints.
Does Lithium in Tap Water Keep Dementia at Bay?
Danish study correlates higher natural levels of lithium to lower incidence of Alzheimer’s disease
Amyloid-β Fibril Structure Bares All
CryoEM reveals high-resolution view of full length of Aβ42 in a novel conformation.
Can Aβ Seeds Be Transferred During Neurosurgery?
Researchers claim that young cases of cerebral amyloid angiopathy may have been caused by contaminated surgical equipment.
Cannabinoid Receptors and AD: Searching Beyond the Simple Story
Researchers from Spain describe changes in cannabinoid receptors in the brains of AD patients, as well as...
Confirmed: Human Pituitary Extract Linked to Amyloidosis Contains Aβ Seeds
The material, previously used to treat children with growth deficiencies, triggered amyloid deposition in transgenic mice.
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