Larry Sparks, of Alzheimer’s-Cholesterol Fame, Dies at 63
Alzheimer's disease researchers expressed sadness this week at the sudden death of Larry Sparks...
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Doubling Rab5 in Mice Leads to Neurodegeneration—Without Plaques
Overexpressing the endosomal activator in neurons not only caused those organelles to swell, but also bungled synaptic transmission, goaded hyperphosphorylation of tau, and destroyed cholinergic neurons.
Dementia Researchers Commend FDA Crackdown on Supplement Hype
When the agency sent warning letters to 17 companies that falsely advertised cures and preventions for AD, most took down exaggerated claims. But can regulations stay ahead of the market?
Aberrant Networks in Alzheimer’s Tied to Herpes Viruses
Big data analyses correlate viral load with clinical, molecular, and pathological features of AD. Time to consider the pathogen hypothesis anew?
Varicose Axons: Traffic Jams Precede AD Pathology in Mice, Men
Early in the course of Alzheimer disease, blockages in axonal traffic lead to sick axons swollen with the jumbled pile-up of traffic components. The blockages precede...
Aβ Star is Born? Memory Loss in APP Mice Blamed on Oligomer
In a clever bit of sleuthing, Karen Ashe and colleagues appear to have solved the case of the mysterious...
Philadelphia: All Is Not Well with the Statin Story
One of the field’s biggest hopes for a quick and easy new AD therapy received a punch in the stomach today...
Statins and AD—What Role Isoprenoids?
There has been considerable excitement generated by findings that statins, which lower plasma cholesterol, may help protect against Alzheimer disease...
Keystone: Death Receptor Ligand—New Role for APP, New Model for AD?
At the Keystone symposium on Wednesday, debate on the last plenary talk continued around the dinner table and well into the poster session...
Genetic Testing a Foggy Crystal Ball at Best?
Sequencing a person’s entire genome will foretell many diseases only marginally better than gazing into a crystal ball...
CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate
The 5th Clinical Trials in Alzheimer’s Disease conference offered new data from ongoing analyses of the Phase 3 programs on solanezumab and bapineuzumab...
Early Intervention Trial Bears Little Fruit, but Sows Hope
Is the glass half empty or half full? Alzheimer disease clinicians might be asking themselves that question after seeing the long-awaited results of...
Cholinergic Transmission and Aβ: Boosting M1 Receptors Treats Model
An impressive data set that appeared yesterday in Neuron shows that a specific M1 muscarinic receptor agonist can...
Coping with Copper—Minute Amount of Metal Plagues Rabbit Brain
This week's PNAS early online edition reports that, depending on the diet, even minor amounts of copper can lead to both amyloid plaques and a memory deficit in rabbits...
Nicastrin—A DAPper Role in γ-Secretase
Though we've known for some time now that the protein nicastrin is a major player in the γ-secretase complex...
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