Crucial Cluster: MicroRNAs Keep Motor Neurons Alive
The motor neurons most sensitive to ALS require a microRNA cluster to survive, lest PTEN activates apoptosis.
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The motor neurons most sensitive to ALS require a microRNA cluster to survive, lest PTEN activates apoptosis.
A new study reports that Aβ disturbs sleep patterns that help cement memories.
A genetic polymorphism in the human prion protein that shielded cannibalistic tribe members from the disease kuru could help researchers understand the structural biology of Creutzfeldt-Jacob disease.
Arizona State University and Banner Health are hiring 20 scientists and their teams for a joint research institute dedicated to neurodegenerative diseases.
Tiny mesh electronics fold up neatly into the needle of a syringe and can be injected into the brain. The devices record neurons, and may do more in the future.
A new approach identifies a set of synaptic genes that influence the strength of connections in large brain networks.
One author falsified figures, prompting the lab to request a retraction.
The enzyme complex directly cleaves a protein crucial for survival of B cells, debuting a new type of substrate for the protease.
The mice, which lack the ALS- and FTD-linked gene in neurons, indicate that C9ORF72 loss of function alone cannot cause neurodegeneration.
Live imaging combined with mathematical modeling suggests that dendritic spines in the hippocampus disappear on the same time schedule as short-term memories fade.
The scale of cortical folding in mammals—from rodents to humans—is dictated by a simple relationship between surface area and thickness.
A Phase 2b trial finds that the monoamine oxidase B inhibitor sembragiline missed its primary endpoint.
By recording from individual human brain cells, researchers find that single neurons can instantly encode associations, showing how rapidly they form memories.
Methylation of cytosines that do not precede guanine bases in DNA prominently occurs in the brain, but not the rest of the body. This epigenetic mark may play a role in Rett syndrome.
A protein that accumulates in the blood of old mice impairs memory and neurogenesis.