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Neurogenesis and Memory

It is now generally accepted that new neurons are generated in the adult mammalian brain, but until now it has been unclear whether or not these neurons are essential for memory formation...

Mitochondrial Exports

A British and German team has made the surprising discovery that the cell's mitochondria can export peptides into their surrounding environments. Much is known about how mitochondria import proteins, but the role of this unexpected export mechanism...

Mouse (Gene) Trap

Understanding the mechanisms regulating brain wiring has until now relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular clues. This week...

"Mad Yeast"?

This week Peter Chien and Jonathan Weissman of the University of California, San Francisco, explain how they used two species of yeast (and an artificial yeast prion protein to investigate how prions jump the species barrier...

Amyloid Not an Aberration?

Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations...

β-Secretase a Clean Therapeutic Target

The most promising target for an Alzheimer's therapy in the short term may be the enzyme β-secretase, suggest two papers in the March issue of Nature Neuroscience. Two separate groups have found that mice lacking the BACE1...

Exelon Dose Revised

According to a "Dear Healthcare Provider" letter dated January 26 and posted this week on the Web site of the U.S. Food and Drug Administration, patients who take breaks in Exelon...

Neprilysin Steps out of the Shadows

The enzyme neprilysin—capable of degrading Aβ42 peptide—is a new player in the Alzheimer's disease mystery. Writing in Neuroscience Letters, Patrick McGeer's group at the University of British Columbia adds critical circumstantial evidence...

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