World Alzheimer Conference 2000: Maybe Plaques Kill Neurons after All
Although there are many reports of neurotoxic effects of amyloid when applied to neurons in culture, the evidence for toxicity in vivo has been...
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World Alzheimer Conference 2000: Drosophilae in the Emulsifier
The centrality of the amyloid hypothesis for AD pathology is evident at the World Alzheimer Congress 2000, not only by the sheer number of papers and posters devoted to it, but also by...
World Alzheimer Conference 2000: Huang Poster
The potential contribution of ApoE to AD pathology was cast in a novel light in data presented as a poster today by Huang et al. They were studying the fate of ApoE when expressed by transient transfection in Neuro-2a cells...
World Alzheimer Conference 2000: Neuroinflammation in AD
It has been a century since Alzheimer and Bielchowsky reported senile plaques (SP) in AD brain, but it was only relatively recently appreciated that SPs are embraced by reactive astrocytes and microglia...
A Common Principle of Neurodegenerative Cell Death?
Do individual neurons gradually waste away in inherited neurodegenerative diseases, or are they functioning more or less normally until one catastrophic event does them in? A study published in tomorrow's Nature suggests...
World Alzheimer Conference 2000: Symposium on Therapeutic Approaches
One of the first symposia of the conference was dedicated to an overview of the current and future treatments for AD. Six presenters gave their perspectives on many treatment issues...
World Alzheimer Conference 2000: Symposium on ApoE
Amyloid plaques are still the main attraction, and tangles have certainly not left the stage, but there is still a lot of interest at this meeting (off-Broadway, so to speak) in other potential players in AD pathology...
World Alzheimer Conference 2000: De la Monte Receives Alzheimer Medal
The editors of the Journal of Alzheimer Disease announced today that Suzanne de la Monte was the recipient of its Alzheimer Medal for best article published in the past year...
Can Adult Mice Grow New, Functional Cortical Neurons?
Transplanted stem cells have provided compelling news stories in recent years, promising regeneration of damaged nervous systems, but another possibility—that the adult brain itself could provide the pluripotent cells...
Toward Visualizing Plaques in Vivo
One of the challenges to diagnosing Alzheimer's disease is the lack of a nonbehavioral clinical test. The definitive diagnosis can only be made when amyloid plaques and neurofibrillary tangles are seen at autopsy...
Packaging Therapeutic Genes to Survive the Journey
Finding a safe way to get therapeutic genes past the blood-brain barrier has led to some interesting approaches using the barrier's own transport systems to shuttle DNA across the blood capillary wall...
Noose Tightens Around Presenilin
Results presented by three research groups this week all confirm that presenilin is, at the least, essential for γ-secretase to cleave amyloid precursor protein in the process that releases amyloid-β-...
Huntington's Damages May Be Reversible
The discovery that Huntington's disease results from a particular mutation of the gene for the protein dubbed "huntingtin" has created great hope that this neurodegenerative movement disorder will soon have effective treatments...
Finding the Time to Store a Memory
How are short-term memories converted to long-term memories? The process is certain to be complex, and a study in the 23 June issue of Science suggests thetranscription factor NPAS2 may play an important role...
World Alzheimer Conference 2000: It’s Fibrillogenesis, Not the Fibrils!
Peter Lansbury, like I and others, has long promulgated the idea that intermediates in CNS disease-related fibrillogenesis processes are likely to be pathogenic, whereas mature matted fibrils (although not desirable) are relatively inert...
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