Huntingtin Protein’s First Act: Overexciting Synapses
A new fly model of Huntington disease (HD) reveals a novel pathogenic mechanism for the polyglutamine-expanded huntingtin protein...
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A new fly model of Huntington disease (HD) reveals a novel pathogenic mechanism for the polyglutamine-expanded huntingtin protein...
You can’t keep a good mitochondrion down. Or maybe you can...
Lithium is an old and much used psychiatric drug, whose mechanism of action remains murky...
A transcriptome database comparing gene expression of cell types highly purified from fresh mouse brain is offering a trove of new information...
After messenger RNA, there were microRNAs, and with them the growth and development of cells and organisms...
Epigenetic changes mediated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) are implicated in normal memory function and in neurodegenerative disease...
One neuron can make a difference, especially if it sheds light on how its billions of neighbors conspire to form functional neural circuits in the brain...
This concludes Gabrielle Strobel’s 5-part series...
Enabling Technologies for Alzheimer Disease Research: Seventh Bar Harbor Workshop, 2007, Part 1 Enabling Technologies for Alzheimer Disease Research: Seventh Bar Harbor Workshop, 2007, Part 2 Enabling Technologies for Alzheimer Disease Research: Seventh B
The technological limitations to studying Alzheimer disease remain major...
In Alzheimer’s and related neurodegenerative diseases, misfolded proteins that normally are degraded instead accumulate and form aggregates...
Apolipoprotein E (ApoE) was first identified in the 1970s as playing a role in regulating plasma cholesterol levels, and in genetic hyperlipoproteinemias...
Last August, Alzheimer disease researchers met with colleagues from other scientific fields for the seventh annual workshop on Enabling Technologies for Alzheimer Disease Research...
Close neighbors can often influence each other’s behavior. The same seems true for neuronal synapses...
Lowering the antioxidant defenses of dopaminergic neurons in mice leads to the mitochondrial dysfunction and age-related neurodegeneration characteristic of Parkinson disease...
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