Fighting Fire With Fire—Transthyretin Therapy for Aβ?
Transthyretin is one of a handful of proteins that, like amyloid-β, can adopt a β-sheet conformation and aggregate as amyloid...
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Transthyretin is one of a handful of proteins that, like amyloid-β, can adopt a β-sheet conformation and aggregate as amyloid...
It’s safe to assume that for most Alzheimer researchers, the concept of a “supermodel” does not involve long legs and a pretty face...
Elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function and axonal transport...
Fundamental knowledge gaps in Alzheimer disease research include a clear grasp of the normal role of the amyloid precursor protein (APP), and the molecular basis for the increased risk for AD as people age...
Thanks to a new imaging technology, researchers discovered that amyloid plaques can literally show up overnight and grow to their full size in just a few days...
A new functional MRI (fMRI) study shows how two regions of the brain prominently affected in Alzheimer disease cooperate to form new memories...
That new neurons are born in the adult mammalian brain is by now a foregone conclusion...
The discovery of microRNAs (miRNAs) opened a door on a previously unsuspected world of genetic regulation...
Blocking amyloid fibrillization with small molecules is a widely studied strategy for tackling Alzheimer disease and other amyloidoses...
Parkinson disease (PD) is a bit of an enigmatic mix...
To stop the destruction of neurons in Alzheimer disease requires an understanding of how the two protein perpetrators, amyloid-β and tau do their dirty work...
Transient episodes of neurological symptoms—muscle weakness, double vision, or other signs that last less than 24 hours—reveal underlying circulatory problems in the brain...
Is it futile to buck the trend that insulin resistance and dysfunctional insulin/insulin-like signaling contribute to neurodegeneration?...
A paper in the Journal of Clinical Investigation online supports the idea that ABCA1 can protect against amyloid buildup...
Can an FDA-approved arthritis drug double as a therapy for Alzheimer disease?...
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