In AD mouse brain, transplanted human neurons develop more tau pathology and die more readily than neighboring mouse neurons.
Produced by the dreaded MRSA bacterium, PSMα3 is the first known example of a natural peptide that forms amyloid fibers made not of β-sheets, but of neatly stacked α-helices.
A well-controlled trials shows that a year of treatment offers no cognitive benefit for older men with low testosterone levels.
The extracellular fragment of TREM2, but not of its AD variants, promotes microglial survival, activation. To do that, it does not need the full-length TREM2 receptor.
Growing expansions in the C9ORF72 gene may lead to earlier onset of amyotrophic lateral sclerosis and/or frontotemporal dementia symptoms with each passing generation.
Thousands of hits on the ol’ noggin during a soccer player’s career might lead to concussive symptoms and, eventually, dementia.
The EPOCH trial of verubecestat was halted for lack of efficacy. APECS trial in prodromal AD continues.
In cell cultures, excess cytoplasmic TDP-43 shut down global translation and triggered formation of protein inclusions.
Transgenic mouse models devoid of gut microbes make fewer Aβ plaques.
Using yeast as springboard, researchers deploy a new computational tool to trace the biology driving α-synuclein pathology in people. The hope: to find pathways that will inform future therapies.
Speaking two languages enhances connections within the brain, which may compensate for neurodegeneration.
A simple blood draw may help distinguish garden-variety PD from other, less common parkinsonian disorders early in disease.
Neurons of the humble roundworm pack damaged organelles and protein aggregates into giant vesicles and heave them out into extracellular space. Do our neurons do that, too?
In rats, stimulation of astrocytes boosted the signal from micro-FDG PET, suggesting these scans may reflect more than just neuronal activity.
In induced cells from people with a C9ORF72 expansion, the number of mutant transcripts matched the number of RNA foci per cell.