In AIBL, memory declines as people with brain amyloid age. Without amyloid, episodic memory keeps steady, even in ApoE4 carriers.
Cryoelectron tomography yields pictures suggesting that poly-Gly-Ala peptide repeats form proteasome-trapping ribbons inside neurons.
Mutations spur fibrillization, while methylation and autophagy keep droplets nice and fluid.
Pinching the Aβ spigot with BACE1 inhibition doesn’t shrink plaques. It does slow their growth and stops new ones from forming. Is that going to be good enough?
Using a new fluorescent sensor, researchers recorded temperatures close to 50°C in these cellular energy plants.
The trial’s sponsor announced an early end to the large Alzheimer’s prevention study based on an interim futility analysis.
The more risk variants in a person’s genome, the faster they decline on both cognitive and motor tests.
Antibody comes close, but can’t slow mild AD.
In ADNI, only a handful of variants associate with amyloid PET. Their impact may vary by disease stage.
Three new studies agree that cellular stress favors noncanonical translation of dipeptide repeats from an intron in the C9ORF72 gene, but diverge on the exact mechanism.
Scientists elucidate a new pathway by which salt triggers adaptive immune cell responses in the gut, which harm memory without driving up blood pressure.
A pilot study finds that depriving people of sleep bumps up their nightly Aβ production.
The shed domain of this microglia receptor sticks to plaques and neurons. Not so for the R47H AD variant, however.
Using whole-genome sequence analysis, researchers find genetic variants linked to white-matter integrity, and cerebral and hippocampal volume.
A new protein-labeling technique puts TDP-43 on the growing list of neurodegeneration-associated proteins that displace nucleoporins and nuclear transport factors.