Does Serotonin Pathology Foreshadow Parkinson’s Disease?
In carriers of a PD-causing mutation, PET scans showed serotonin transporter loss before motor symptoms set in.
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In carriers of a PD-causing mutation, PET scans showed serotonin transporter loss before motor symptoms set in.
Through an endocytic process called LANDO, microglia clear β-amyloid and route their used Aβ receptors, including TREM2, back to the plasma membrane. Without it, aggregates pile up outside and form plaques.
Two groups create mice for imaging and manipulation of microglia, leaving related cells untouched. The trick? Piggybacking on Tmem119 expression.
Today, the creators of bioRχiv launch a repository for preliminary medical research, including clinical trial data.
Fully automated immunoassay could offer cost-effective screening for AD.
A meta-analysis of 47 studies suggests CSF NfL is particularly elevated in a select few, suggesting it could help in differential diagnosis.
In response to the peptide, these little cells squeeze capillaries, constricting them. This may contribute to neuronal dysfunction.
New strains have amyloid, neurodegeneration, and neuroinflammation, all against a background of natural genetic variation.
In healthy, older adults specific EEG patterns correlated with plaque and tangle burdens.
Using different techniques, contestants vied for the best way to tell which ADNI participants would develop clinical, cognitive, or imaging signs of Alzheimer’s disease.
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