Are high-molecular-weight, multi-protease complexes cellular Aβ factories?
In familial Alzheimer’s disease, rise in NfL in the blood precedes disease onset by 16 years.
In neurons derived from FTD patients, microtubules distort the nucleus, warping its normally rounded membrane and disrupting communication with the cytoplasm.
Stakeholders have until February 11 to comment on draft FDA guidance for biomarker qualification.
Two independent studies find that loss of nuclear TDP-43 leads to mis-splicing of stathmin 2, an essential protein for axon growth and repair.