Target BACE: Better Than Ever?
In yesterday’s Neuron, researchers presented fresh in-vivo support for the amyloid hypothesis and bolster the status of the APP protease BACE as the current favorite target for AD therapy development...
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In yesterday’s Neuron, researchers presented fresh in-vivo support for the amyloid hypothesis and bolster the status of the APP protease BACE as the current favorite target for AD therapy development...
Genome, transcriptome, proteome, and now we have the interactome, the full complement of protein-protein interactions that can occur in the cell...
Results are in from the first pilot study to test the potential benefit of clioquinol in Alzheimer's disease patients, suggesting that the drug improves cognition and lowers plasma levels of Aβ42 in some patients...
Localized gene transfer has produced the first rat model of neurofibrillary tangles, announce the authors of a report in the January 2004 American Journal of Pathology...
Two recent studies confirm that local inflammation inhibits adult neurogenesis in the hippocampus and, in a promising advance, they find evidence that...
As government officials scramble to contain the current scare over a cow that tested positive for BSE in Washington state earlier this week, researchers in New York and Boston report...
A report in last week's Cell suggests that TGF-β1, one of the three mammalian isoforms of that growth factor, can protect against excitotoxic neurodegeneration...
Scientists prospecting the amyloid hypothesis for new treatment strategies have set their sights on the idea of boosting the enzymatic destruction of the Aβ peptide...
A study of Swedish twins, including many over the age of 80, leads researchers to conclude that the genetic contribution to late-onset Alzheimer's disease is not as great as previously estimated...
Protein folding aficionados may well want to hold on to their December 18/25 copy of Nature, which devotes a special insight section to the topic...
The research group that originally identified the Parkinson's mutations reveals that DJ-1 may also play a role in the formation of neurofibrillary tangles found in Alzheimer's and of similar bodies...
Reports in the 12 December issue of Cell reveal that post-translational modification of proteins may play a crucial role in two key steps required for protein removal—proteasomal degradation and transportation...
Despite the complications encountered with vaccines for Alzheimer's disease antibody therapy still has potential as a therapeutic. The December 3 Biochemistry reports a new variation on the antibody theme...
Melatonin does not appear to be useful in helping most Alzheimer's patients achieve a good night's sleep, according to a study in the November issue of the journal Sleep...
A case report in the December 5 issue of the New England Journal of Medicine presents an example of the potential dangers of anticholinergic drugs in some patients: short-term memory loss and hallucinations...