NGF, Galantamine Rescue Anti-NGF Model of Alzheimer's
A mouse model that claims to reproduce AD pathology more completely than APP transgenics appears to respond to treatment with NGF and a cholinergic drug.
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Chaperones and Proteasomes In Neurodegeneration
Two current reviews lay out the current understanding of the role of protein-folding assistants and protein grinders in neurodegenerative diseases.
RNAi—It’s Not Just for Fibroblasts Anymore, But Neurons Too
Small interfereing RNAs are a hot new tool to manipulate gene expression. Read here about how to apply this method to primary neuronal cultures.
Aging with the Right Memory Molecules
This week's issue of Nature features two articles that point to ways in which the targeting of molecules associated with maintenance of cognitive function might one day help boost these functions in both normal and demented older adults.
Novel Cell-Based Parkinson's Model Shows Promise
Using chronic, low-level exposure to a pesticide, Timothy Greenamyre's group has produced a new in-vitro model that recapitulates significant aspects of the cellular damage thought to underly Parkinson's disease.
Neutralizing Nogo Allows Spinal Cord to Rewire Correctly
Read about this update of Martin Schwab's efforts to rekindle spinal cord regeneration with antibodies against the growth inhibitor nogo.
Mutant Proteins—Is it Quality or Quantity that Counts?
Open reading frame point mutations are associated with a variety of diseases, including Alzheimer’s, and many of these mutations destroy the function of the protein in question. But what of the expression level of the mutated gene? This question was addressed by Kenneth Kinzler...
p53 as Mediator of Oxidative Stress and Inflammation?
The tumor suppressor p53 appears to play a role in the pathogenesis of rheumatoid arthritis. What about Alzheimer's disease?
Amyloid in Transgenic AβPP Mice Affects Blood Flow
A study by Swiss researchers suggests that fMRI can measure how amyloid changes cerebral blood flow in transgenic mice.
Hot Spots of Genetic Rearrangement as Predictors of Disease
Could analyzing gene duplications help identify those elusive Alzheimer's genes?
Gingko Is a No-Go
A widely used alternative treatment has again come up short in rigorous testing.
Caloric Restriction Increases Metabolic Rate
It has been known for sometime that reduced intake of calories increases the lifespan of many species, including mammals, but just exactly how this works is unclear. Now work from Leonard Guarente’s lab at MIT suggests that <em>increased</em> respiration is what extends lifespan—at least in yeast....
New Role for NO in Neuronal Apoptosis
In today’s Science, researchers from the Burnham Institute, La Jolla, California, report a new pathway that can cause neuronal apoptosis, or programmed cell death—the covalent modification of extracellular matrix metalloproteinases (MMPs)....
Fat and Calories Mean Higher AD Risk
When it comes to food and the quality of life there is a growing wealth of knowledge that suggests “less is more.” This mantra is supported by a new study associating high caloric intake with increased risk for Alzheimer’s disease (AD)....
Adult Stem Cells—Ready and Willing, but Vulnerable
Research reported in the online Nature Medicine reinforces the potential of adult stem cells to repair the damaged or diseased brain, but it also points out the extent to which these cells are dependent on a healthy microenvironment.
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