Sniffer Snuffs Out Stress, or Does Aging Boil Down to Oxidation?
Evidence linking mitochondrial oxidative stress with neurodegeneration has been pouring forth lately. But news of novel mechanisms...
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Evidence linking mitochondrial oxidative stress with neurodegeneration has been pouring forth lately. But news of novel mechanisms...
Despite the vastly heterogeneous nature of mammalian brains, researchers are pressing on with gene profiling experiments aimed at...
Last week, both ends of the nerve growth factor (NGF) research spectrum advanced by a step. On its fundamental science, an article in Science describes...
If aggregates of the sticky amyloid-β can contribute to the pathology of Alzheimer’s disease (AD), then maybe unsticking them will help reverse the process...
May 1 2004. Cells of the blood lineage, introduced into patients receiving bone marrow transplants, are reported to have given rise to brain cells. The finding reawakens hope that stem cells from diverse organs may one day be used to repair damage in other types of tissue...
The clamp, the boot, whatever you call it, if you find one on your car you’ll appreciate how a seemingly small attachment can keep its wheels from turning. In today’s Sciencexpress, researchers report that covalently clamping parkin with nitric oxide...
Do solitary Aβ peptides begin their journey toward insoluble plaques by meeting up with partners on lipid rafts in the plasma membrane? Researchers report evidence that, in an APP-transgenic mouse model, Aβ dimerizes in the rafts and, what's more...
Priming the immune system to recognize and clear endogenous antigens from the nervous system has always been a controversial therapeutic strategy. We only have to look to...
The Aβ-binding alcohol dehydrogenase (ABAD) forms a complex with Aβ in mitochondria, promoting leakage of free radicals, mitochondrial dysfunction, and cell death...
Designed to speed transport and communication, bridges may also be useful for slowing disease. Researchers suggest as much in their review of one promising strategy for slowing the progression of ALS...
Last month, the commercial conference planner IBC Screentech held a conference on drug development approaches in neurodegeneration in San Diego, California, as part of its World Summit series...
Mutations in Pink1, a gene coding for a mitochondrial protein kinase, has just been fingered as a genetic cause for parkinsonism. In today’s Sciencexpress, researchers report that Pink1 and PARK6, a long-sought-after genetic locus that is linked with early-onset Parkinson’s disease, are...
Anyone who has minced beef knows that the grinder occasionally gets clogged by a particularly tough bit of meat or gristle. Polyglutamine (polyQ) stretches, it turns out, may have a similar effect on our intracellular protein grinder, the proteasome...
When it comes to the biological activity of Aβ, a question often pondered is: How much is enough? In the March 31 Journal of Neuroscience, Barry Festoff and colleagues suggest that the answer may be...
A transgenic <em>Drosophila</em> model of AD shows learning deficits, reduced lifespan, amyloid buildup, and neurodegeneration in response to expression of human Aβ42...