Polyglutamine, Inclusion Bodies and the Proteasome—The Good, the Bad, and the Innocent?
Are inclusion bodies the fault of the proteasome? Two groups come up with different answers...
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Are inclusion bodies the fault of the proteasome? Two groups come up with different answers...
By amplifying small quantities of Aβ oligomer in cerebrospinal fluid, a methodology referred to as the "bio-barcode" could serve as a diagnostic or monitoring test for AD...
Yesterday the National Institutes of Health announced sweeping new rules restricting...
Combining their individual fortés, researchers treat us to the sight of neurons being "healed" before our eyes...
Par-4, the leucine-zipper protein first found in apoptotic prostate cancer cells, can regulate β-secretase (BACE) cleavage of amyloid-β precursor protein (AβPP)...
Summary by <a href="/scientific-advisory-board">Peter Davies</a>, Albert Einstein College of Medicine. July 2004, Philadelphia...
Last Friday, the pharmaceutical company Johnson & Johnson announced that health authorities were reviewing safety data on galantamine hydrobromide...
As the γ-secretase complex has given up some of its secrets, it has created new puzzles to solve, such as...
Using two-photon microscopy, researchers at Harvard Medical School have peered into the brains of rats and cats to see real-time images...
In last October’s Neuron, researchers revealed that the gene LRRK2, encoding a protein kinase dubbed “dardarin,” is one and the same with...
Light and gravity ensure that tree trunks grow straight up while their roots burrow deep underground. What about neurons?...
In efforts to interfere with Aβ peptide production, most of the attention has been lavished on the β- and γ-secretase enzymes...
You <em>can</em> have too much of a good thing. Glutamate, for example, is one of the major excitatory neurotransmitters, but too much of it....
Taxols, drugs that are commonly used to treat cancer, may offer some therapeutic benefit for patients suffering from Alzheimer disease...
A report reinforces earlier observations that some antipsychotic drugs may increase the risk for, or even cause, diabetes in patients with schizophrenia...